2011 Fiscal Year Final Research Report
Control of crystallization nucleation of organic compounds in recognizing of the importance of solution structure and its application for production of nano crystals
| Project/Area Number |
21560781
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
OOSHIMA Hiroshi 大阪市立大学, 大学院・工学研究科, 教授 (20112526)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IGARASHI Koichi 大阪市立大学, 大学院・工学研究科, 助教 (70315977)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 晶析 / 結晶核形成メカニズム / 粒径と粒径分布 / ナノ結晶 / 有機化合物結晶 / 医薬結晶 / マイクロ波照射 |
|---|
| Research Abstract |
Chemical structure of pharmaceutical compounds evolves to become complex and hard to dissolve. To increase bioavailability of drugs, we must produce fine crystals of drugs by controlling the nucleation step of crystallization. However, the mechanism of nucleation has not been well understood. In the present study, we found for the first time that the control of the change of molecular associate structure and the control of diffusion of molecules are important to control nucleation. Furthermore, we attempted some processes to produce fine crystals.
|
