2011 Fiscal Year Final Research Report
Development of high performance or ganocatalyst using a-hetero atom effects and its application to enantioselective Biginelli reaction
| Project/Area Number |
21590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUZUKI Ichiro 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40294714)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Biginelli反応 / 有機触媒 / 不斉Diels. Alder反応 / α.ヘテロ原子効果 |
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| Research Abstract |
We investigated enantioselective Biginelli reactions using hydrazine. and Hydrazide. based organocatalyst. We found that a chiral pyrazolidine-based catalyst showed only low efficiency, whereas parent pyrazolidine showed high catalytic performance. We further developed diamino oxazolidinone type organocatalysts and found that these catalysts showed high efficiency in enantioselective Diels-Alder reactions.
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Research Products
(19 results)
