2011 Fiscal Year Final Research Report
Development of a cancer treatment technique using intracellular collapsing liposomes directed to cancer with double safety systems
| Project/Area Number |
21590115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAGAMUNE Hideaki 徳島大学, 大学院・ソシオテクノサイエンス研究部, 教授 (40189163)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOYASU Toshifumi 徳島大学, 大学院・ソシオテクノサイエンス研究部, 准教授 (20323404)
TABATA Atsushi 徳島大学, 大学院・ソシオテクノサイエンス研究部, 助教 (10432767)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 医薬分子設計 / 癌治療法 / DDS / 細菌毒素 |
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| Research Abstract |
We aimed to develop a novel effective and safe technique for cancer treatment using bacterial toxins with dual safety systems. First, a targeting toxin with safety system and the variable targeting ability was developed. It was confirmed that the liposomes enclosed anticancer drug prepared by using the targeting toxin and anti-carcinoembryonic antigen(CEA) IgG could specifically target to CEA-positive cancer cells and were effective to prolong life of mice inoculated with CEA-positive cancer cells. The second cytotoxic effector toxin with safety system was also produced, so the development of a novel technique for the target-variable cancer treatment using both toxins with safety systems came in sight.
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