2013 Fiscal Year Final Research Report
Probing the catalytic mechnism of ribozymes and breast cancer inhibitory effects based on imidazole C-nucleosides
| Project/Area Number |
21590130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MASANORI Takaoka 大阪薬科大学, 薬学部, 教授 (50140231)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | イミダゾール / C-リボヌクレオシド / リボザイム / テトラゾール / ヒスタミンH3受容体 / アンタゴニスト / 乳癌 |
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| Research Abstract |
Tetrazole C-nucleoside phosphoramidites,efficient synthesis of tetrazoles,and imidazole base pairing effects on DNA,and synthesis of H3R antagonist (OUP-186) as anti-cancer agents were carried out.
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