2011 Fiscal Year Final Research Report
Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stress
| Project/Area Number |
21590145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SADAKANE Yutaka 鈴鹿医療科学大学, 薬学部, 教授 (60293304)
KOYAMA Hironari 九州保健福祉大学, 薬学部, 助手 (70567718)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 中毒学 / 無機金属毒性 |
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| Research Abstract |
Zinc(Zn) is neurotoxic and causes neurodegeneration following transient global ischemia and plays a crucial role in the pathogenesis of vascular-type dementia. We investigated the molecular mechanisms of Zn-induced neurotoxicity in vitro. The analysis of upregulated genes during Zn-induced neuronal death revealed that the significance of ER stress. These new results indicate that the disruption of Ca2+homeostasis and ER stress in the molecular mechanism of Zn-induced neurotoxicity, and are useful for the search for protective substances for vasucular dementia.
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