The function ofsemaphorin in the formation of neural network

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590196
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Sapporo Medical University
• Principal Investigator: TANIGUCHI Masahiko 札幌医科大学, 医学部, 准教授 (70260346)
• Project Period (FY): 2009 – 2011
• Keywords: 神経発生 / 軸索ガイダンス / 脳神経 / ノックアウトマウス

Research Abstract

During embryogenesis, axons reach their specific targets correctly to form the complex neural network found in the mature functional nervous system. Several groups of axon guidance molecules such as semaphorins, ephrins, netrins, and Slits have been reported to repel or attract growing axons that express their cognate receptors. Herein, I report the cloning and characterization of novel semaphorin genes. These semaphorin genes might repel axons of the specific types during development.

Research Products

• [Journal Article] Osteoprotection by semaphorin 3A (2012)
  • Author(s): Mikihito Hayashi, Tomoki Nakashima, Masahiko Taniguchi, Tatsuhiko Kodama, Atsushi Kumanogoh and Hiroshi Takayanagi
  • Journal Title: Nature Volume: 485 Pages: 69-74
  • DOI: DOI:10.1038/nature11000
  • Peer Reviewed
• [Journal Article] Syntaxin 1B suppresses macropinocytosis and Semaphorin 3A-induced growth cone collapse (2011)
  • Author(s): Hiroyuki Kabayama, Makoto Takeuchi, Masahiko Taniguchi, Naoko Tokushige, Shunji Kozaki, Akihiro Mizutani, Takeshi Nakamura and Katsuhiko Mikoshiba
  • Journal Title: J. Neurosci. Volume: 31 Pages: 7357-7364
  • DOI: DOI:10.1523/JNEUROSCI.2718-10.2011
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel zebrafish semaphorin (2011)
  • Author(s): Masahiko Taniguchi, Tomoyuki Masuda, Yoshinori Mikami, Masafumi Kimura, Tomoyuki Yoshida, Masayoshi Mishina and Takao Shimizu
  • Journal Title: Neurosci. Lett. Volume: 488 Pages: 215-220
  • DOI: DOI:10.1016/j.neulet.2010.11.032
  • Peer Reviewed
• [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics via by activating myosin II (2010)
  • Author(s): Hyota Takamatsu, Noriko Takegahara, Yukinobu Nakagawa, Michio Tomura, Masahiko Taniguchi, Roland H. Friedel, Helen Rayburn, Marc Tessier-Lavigne, Yutaka Yoshida, Tatsusada Okuno, Masayuki Mizui, Sujin Kang, Satoshi Nojima, Tohru Tsujimura, Yuji Nakatsuji,Ichiro Katayama, Toshihiko Toyofuku, Hitoshi Kikutani, Atsushi Kumanogoh
  • Journal Title: Nature Immunol. Volume: 11 Pages: 594-600
  • DOI: DOI:10.1038/ni.1885
  • Peer Reviewed
• [Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in Sema3A mutant mice (2009)
  • Author(s): Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Takako Okada, Yutaka Uchida, Masahiko Taniguchi, Toshio Ohshima and Yoshio Goshima
  • Journal Title: J. Comp. Neurol. Volume: 216 Pages: 360-375
  • DOI: DOI:10.1002/cne.22125
  • Peer Reviewed
• [Journal Article] Ca2+induces macropinocytosis via F-actin depolymerization during growth cone collapse (2009)
  • Author(s): Hiroyuki Kabayama, Takeshi Nakamura, Makoto Takeuchi, Hirohide Iwasaki, Masahiko Taniguchi, Naoko Tokushige and Katsuhiko Mikoshiba
  • Journal Title: Mol. Cell. Neurosci. Volume: 40 Pages: 27-38
  • DOI: DOI:10.1016/j.mcn.2008.08.009
  • Peer Reviewed
• [Presentation] Ca2+induces macropinocytosis via F-actin depolymerization during growth cone collapse (2009)
  • Author(s): Hiroyuki Kabayama, Takeshi Nakamura, Makoto Takeuchi, Hirohide Iwasaki, Masahiko Taniguchi, Naoko Tokushige and Katsuhiko Mikoshiba
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-30