2011 Fiscal Year Final Research Report
Insulin secretion in pancreaticβcells and control of blood glucose level studied by fiber-coupled micro endoscopy
| Project/Area Number |
21590231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Toyohashi University of Technology (2011)
Hamamatsu University School of Medicine (2009-2010) |
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Principal Investigator |
SAKURAI Takashi 豊橋技術科学大学, エレクトロニクス先端融合研究所, 特任准教授 (50283362)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生理学 / 細胞・組織 / 生体・分子 / 糖尿病 / バイオ関連機器 |
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| Research Abstract |
To elucidate physiological functions of multiple cells or organs exsising deep inside body, we developed a branch-type fiber-coupled confocal microscope(FCM). The spatio-temporal performance of FCM was enough to resolve the fluorescently-labelled granules in the pancreaticβcells. By using FCM, we could measure glucose-dependent fluorescent intensity changes in theβ-granules reflecting secretion of insulin to the blood stream. The FCM may be usefull technique for the understanding of mechanisms or disorders controlling of the blood glucose level.
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