2011 Fiscal Year Final Research Report
Sharing pathogenic mechanism between non-alcoholic steatohepatitis and primary biliary cirrhosis
| Project/Area Number |
21590433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Toyama |
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Principal Investigator |
TSUNEYAMA Koichi 富山大学, 大学院・医学薬学研究部(医学), 准教授 (10293341)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疾患モデル動物 / NASH, PBC,酸化ストレス |
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| Research Abstract |
Pathological characteristics of non-alcoholic steatohepatitis(NASH) and primary biliary cirrhosis(PBC) were examined. Obese female NASH patients of the older age have a tendency to show PBC-mimicking biliary damages, portal inflammation as well as autoantibodies. Similar pathological changes were observed in older aged female NASH mice model. In contrast, NASH features were not observed in any PBC model mice. In visceral fat of NASH mice model, TNF-αor IL6-positive macrophages aggregation was detected. In drug-induced liver injury mice model, estrogen pretreatment reduced inflammatory severity, while progesterone pretreatment enhanced it. We hypothesized that effects of inflammatory cytokines in the obesity women were enhanced by hormonal imbalance, and easy to cause biliary damages and portal inflammation.
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Research Products
(25 results)
