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2011 Fiscal Year Final Research Report

Analysis of the robust antibody-production of memory B cells

Research Project

  • PDF
Project/Area Number 21590529
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ADACHI Takahiro  東京医科歯科大学, 難治疾患研究所, 准教授 (50222625)

Project Period (FY) 2009 – 2011
Keywords免疫記憶 / シグナル伝達 / B細胞 / カルシウムシグナル
Research Abstract

To analyze the mechanism of rapid and robust antibody production from memory B cells, we identified a subset of B cells from immunized mice, which induced antigen-induced signaling. We generated proteinaceous calcium rpobe, Cameleon,-expressing mice in which calcium signaling of B cells can be monitored.

  • Research Products

    (9 results)

All 2012 2011 2009 Other

All Journal Article (4 results) Presentation (3 results) Book (2 results)

  • [Journal Article] CD22 serves as a receptor for soluble IgM.2012

    • Author(s)
      Adachi T, Harumiya S, Takematsu H, Kozutsumi Y, Wabl M, Fujimoto M, Tedder TF
    • Journal Title

      Eur J Immunol

      Volume: 42 Pages: 241-7

  • [Journal Article] Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72b congenic mice2009

    • Author(s)
      Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 380 Pages: 193-7

  • [Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells2009

    • Author(s)
      Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T. and Nakada, H.
    • Journal Title

      Biochem J

      Volume: 417 Pages: 673-83

  • [Journal Article] Differential Phosphorylation of Functional Tyrosines in CD19 Modulates B Lymphocyte Activation

    • Author(s)
      Ishiura, N., Nakashima, H., Watanabe, R., Kuwano, Y., Adachi, T., Takahashi, Y., Tsubata, T., Okochi, H., Tamaki, K., Tedder, T. F., Fujimoto, M.
    • Journal Title

      Eur J Immunol

      Volume: 40 Pages: 1192-204

  • [Presentation] 腸管免疫細胞の活性化モニターリングマウスの樹2012

    • Author(s)
      安達貴弘
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      京都
    • Year and Date
      20120000
  • [Presentation] Analysis of signaling through the B cell antigen receptor in memory B cells2011

    • Author(s)
      Adachi, T.
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20110000
  • [Presentation] Signaling through the B cell antigen receptor on memory B cells2011

    • Author(s)
      Adachi, T.
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20110000
  • [Book] 臨床免疫・アレルギー科2011

    • Author(s)
      安達貴弘
    • Total Pages
      213
    • Publisher
      CD70と自己免疫疾患
  • [Book] 臨床免疫・アレルギー科2011

    • Author(s)
      安達貴弘
    • Total Pages
      452
    • Publisher
      メモリーB細胞におけるBCRシグナル伝達

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Published: 2013-07-31  

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