2011 Fiscal Year Final Research Report
Investigation of antithrombotic effects of heme oxygenase-1 on the hypercoagulable state by inflammation or oxidative stress
| Project/Area Number |
21590613
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YACHIE Akihiro 金沢大学, 医学系, 教授 (40210281)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | ヘムオキシゲナーゼ1 / 血栓 / 組織因子 / プラスミノゲンアクチベーター・インヒビター / 一酸化炭 / クルクミン |
|---|
| Research Abstract |
The purpose of the present study was to examine the antithrombotic role of heme oxygenase-1(HO-1) in detail, and to examine whether endothelial HO-1 induced by curcumin or carbon monoxide(CO) endogenously produced by HO-1 contributes to this antithrombotic effect. As a result, CO or endothelial HO-1 induced by curcumin would be effective for the prevention and treatment of hypercoagulable state by inflammation or oxidative stress.
|
