2011 Fiscal Year Final Research Report
Establishment of biomarker panel for the early detection of atherosclerosis and the prevention of the cardio-renal syndromes in obesity and metabolic syndrome-role of the phenotypes and the function of peripheral blood monocytes-
| Project/Area Number |
21590646
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
|---|
Principal Investigator |
SATOH Noriko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Koji 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 部長 (50283594)
KOTANI Kazuhiko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 客員室長 (60335510)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Yoshihiro 東京医科歯科大学, 大学院・医歯学総合研究科・分子内分泌内科学分野, 教授 (70291424)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 内科 / 脂質 / 医療・福祉 / 遺伝子 / 動脈硬化 |
|---|
| Research Abstract |
We have revealed that the phenotypes of monocyte(inflammatory M1 type and anti-inflammatory M2 type : qualitative changes) are significantly associated with the known cardiovascular risks and that unfavorable pro-inflammatory(M1)/anti-inflammatory(M2)-like phenotypes of peripheral blood monocytes are improved by the treatment with diabetic or anti-hyperlipidemic drugs in Japanese patients with obesity and metabolic syndrome from 1050 subjects in the database of National Hospital Organization. Accordingly, these data suggest the efficacy of the measurement of phenotypes of monocytes for early detection of atherosclerosis and the prevention of cardiovascular diseases in obesity and metabolic syndrome.
|
-
[Journal Article]2012
Author(s)
Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Koji Hasegawa K, and Ogawa Y
-
Journal Title
Diabetes Care
Volume: (in press)
Peer Reviewed
-
[Journal Article] Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients2012
Author(s)
Himeno A, Satoh-Asahara N, Usui T, Wada H, Tochiya M, Kono S, Yamada-Goto N, Katsuura G, Hasegawa K, Nakao K, Shimatsu A
-
Journal Title
Metabolism
Volume: 61
Pages: 255-261
Peer Reviewed
-
[Journal Article] α1-Antitrypsin-low-density-lipoprotein Serves as a Marker of Smoking-specific Oxidative Stress2012
Author(s)
Wada H, Ura S, Satoh-Asahara N, Kitaoka S, Mashiba S, Akao M, A be M, Ono K, Morimoto T, Fujita M, Shimatsu A, Takahashi Y, Hasegawa K
-
Journal Title
J Atheroscler Thromb
Volume: 19
Pages: 47-58
Peer Reviewed
-
[Journal Article] Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects2012
Author(s)
Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K
-
Journal Title
PLoS ONE
Volume: 6
Pages: e29351
DOI
Peer Reviewed
-
[Journal Article] The Japan Obesity Metabolic Syndrome Study(JOMS) Group. Serum Amyloid A Low-density Lipoprotein Levels and Smoking Status in Obese Japanese Patients2011
Author(s)
Kotani K, Satoh-Asahara N, Kato Y, Araki R, Himeno A, Yamakage H, Koyama K, Tanabe T, Oishi M, Okajima T, Shimatsu A
-
Journal Title
J Int Med Res
Volume: 39
Pages: 1917-1922
Peer Reviewed
-
-
[Journal Article] Increased Expression of Macrophage-inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans2011
Author(s)
Ichioka M, Suganami T, Tsuda N, Shirakawa I, H irata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y
-
Journal Title
Diabetes
Volume: 60
Pages: 15-19
Peer Reviewed
-
[Journal Article] The Japan Obesity Metabolic Syndrome Study(JOMS) Group. Urinary Cystatin C as a Potential Risk Marker for Cardiovascular Disease and Chronic Kidney Disease in Patients with Obesity and Metabolic Syndrome2011
Author(s)
Satoh-Asahara N, Suga mami T, Majima T, Kotani K, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Himeno A, Kono S, Sugawara A, Masakazu H, Ogawa Y, and Shimatsu A
-
Journal Title
Clin J Am Soc Nephrol
Volume: 6
Pages: 265-273
Peer Reviewed
-
-
-
-
[Journal Article] LOX-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice2010
Author(s)
Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
-
Journal Title
Biochem Biophys Res Commun
Volume: 398
Pages: 576-580
Peer Reviewed
-
-
-
[Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance2010
Author(s)
Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano, T, Fujita M, Kita T, Shimatsu A, Hasegawa K
-
Journal Title
Atherosclerosis
Volume: 208
Pages: 512-517
Peer Reviewed
-
-
[Journal Article] The Japan Obesity Metabolic Syndrome Study(JOMS) Group. Remnantt-like particle cholesterol and serum amyloid A-low-density lipoprotein levels in obese subjects with metabolic syndrome
Author(s)
Kotani K, Satoh-Asahara N, Kato Y, Araki R, Himeno A, Yamakage H, Koyama K, Tanabe T, Oishi M, Okajima T, Shimatsu A
-
Journal Title
J Clin Lipidol
Volume: 5
Pages: 395-400
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
