2011 Fiscal Year Final Research Report
Analysis of polymorphisms and association study of FUT2 and FUT3, regulating synthesis of Lewis blood group antigens.
| Project/Area Number |
21590750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KODA Yoshiro 久留米大学, 医学部, 教授 (90231307)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖転移酵素 / 糖鎖 / 血液型 / 遺伝子多型 |
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| Research Abstract |
The FUT2 and FUT3 regulate the synthesis of the ABO and Lewis blood group antigens. Recent studies have shown these genes were rich in polymorphisms with population-specific manner. We developed new methods to determine not only SNPs but copy number variations of the FUT2 to promote such studies. In addition, we performed analysis of the transcriptional region of the FUT2 and association study of polymorphisms and lifestyle-related diseases.
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[Journal Article] Genetic variation of FUT2 in a Vietnamese population : identification of two novel Se enzyme-inactivating mutations2011
Author(s)
Soejima M, Fujimoto R, Agusa T, Iwata H, Fujihara J, Takeshita H, Minh TB, Trang PT, Viet PH, Nakajima T, Yoshimoto J, Tanabe S, Koda Y
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