2011 Fiscal Year Final Research Report
Comprehensive analysis of pathogenesis and etiology of Takotsubo Cardiomyopathy by use of experimental model animal
| Project/Area Number |
21590771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
UEYAMA Takashi 和歌山県立医科大学, 医学部, 准教授 (50264875)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABE Tetsuya 和歌山県立医科大学, 医学部, 助教 (60508034)
KIMURA Hiroko 順天堂大学, 医学部, 准教授 (00053299)
TSURUO Yoshihiro 和歌山県立医科大学, 医学部, 教授 (90207449)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ストレス / 心身症 / モデル動物 / 脳 / 心臓 / 網羅的発現解析 / 酸化的ストレス |
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| Research Abstract |
We investigated the pathogenesis and etiology of Takotsubo Cardiomyopathy by use of stress-induced rat model. Activation of α1-adrenoceptor in the blood vessels or activation ofβ1-adrenoceptors in the heart was mainly responsible for emotional stress-induced alteration of cardiac and vascular genes profiles. All amygdalid subncleui receive psychological information from other limbic brain, while the lateral and central subnuclei receive peripheral and sensory information. Output to the hypothalamus and peripheral sympathetic system mainly originates from the medial amygdala.
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