2011 Fiscal Year Final Research Report
Targeting anticancer drug delivery to colon cancer cells using a fucose-bound nanoparticle approach
| Project/Area Number |
21590818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SATO Yasushi 札幌医科大学, 医学部, 講師 (80343383)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIMOTO Rishu 札幌医科大学, 医学部, 講師 (10336399)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 糖鎖 |
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| Research Abstract |
Increased expression of fucosyltransferases(FUTs) is common in colic adenocarcinoma cells5. FUTs are key enzymes accelerating malignant transformation through the fucosylation of different sialylated precursors, suggesting a crucial requirement for L-fucose by colic adenocarcinoma cells. We developed L-fucose-bound liposomes as vehicles for delivery of anticancer drugs specifically to these cells. We report that intravenously injected L-fucose-bound liposomes containing Cisplatin were successfully delivered to colic cancer cells, mediating efficient tumour growth inhibition in tumour-bearing mice.
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