2011 Fiscal Year Final Research Report
Elucidation of the phosphatidylinositol metabolism to control steatohepatitis and hepatocellular carcinoma
| Project/Area Number |
21590823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Akita University |
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Principal Investigator |
HORIE Yasuo 秋田大学, 大学院・医学系研究科, 講師 (30282164)
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| Co-Investigator(Kenkyū-buntansha) |
OHSHIMA Shigetoshi 秋田大学, 医学部, 講師 (50375268)
OHNISHI Hirohide 秋田大学, 大学院・医学系研究科, 教授 (00313023)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Takehiko 秋田大学, 大学院・医学系研究科, 教授 (50333365)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝臓学 |
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| Research Abstract |
Deletion of phosphatidylinositol 3 kinase isozymes such as p110α, p110γ, and p110δ did not inhibit development of hepatic lesions in Pten KO mice. Inpp4 is a phosphatase which dephosphorylates PI(3, 4)P2 that is metabolite of PI(3, 4, 5)P3 and has the same function as PI(3, 4, 5)P3, a substrate of Pten. We made clear that Inpp4 or Akt2 and PPARγ, downstream molecules of Pten, played a critical role in development of hepatic lesions in Pten KO mice.
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