2011 Fiscal Year Final Research Report
Mechanisms involved in spontaneous development of hepatocellular carcinoma in mouse model of non-alcoholic steatohepatitis
| Project/Area Number |
21590849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
SAIBARA Toshiji 高知大学, 教育研究部・医療学系, 教授 (60145125)
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| Co-Investigator(Renkei-kenkyūsha) |
TODA Katsumi 高知大学, 教育研究部・医療学系, 准教授 (40197893)
OCHI Tsunehiro 高知大学, 医学部附属病院, 医員 (30617840)
MUNEKAGE Kensuke 高知大学, 医学部附属病院, 医員 (60617843)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝臓学 / NASH |
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| Research Abstract |
This model mouse developed enhanced fatty acid synthesis and its beta-oxidation at the age of 8 weeks. These changes resulted in inflammatory cell infiltration induced by enhanced mRNA expression of scavenger receptor, catalase, IL-1, and IL-8. Supplementation of estradiol attenuated these changes significantly. Accelerated PPAR-alpha is a well-known risk factor for the development of hepatocellular carcinoma and its effective attenuation in such situation could be a novel strategy for the management of NASH patients.
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