Host factor targeting newly developed treatment for HCV

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Showa University
• Principal Investigator: INOUE Kazuaki 昭和大学, 医学部, 准教授 (90232529)
• Project Period (FY): 2009 – 2011
• Keywords: HCV / サイクロフィリン / 宿主因子 / 抗ウイルス剤

Research Abstract

About 200million people are suffering from Hepatitis C virus infection that leads to hepatocellular carcinoma and chronic liver failure. Effectiveness of standard of care is not so sufficient to cure the intractable cases. We have searched for new lead compound targeting host factor that is related to HCV replication using new peptide library. Now we are characterizing new compounds.

Research Products

• [Journal Article] Localization and distribution of viral genomes and proteins are helpful to understand pathogenesis of hepatitis (2011)
  • Author(s): Inoue K, Yoshiba M, Kohara M
  • Journal Title: Global Antiviral Journal Volume: 7(Suppl. 1) Pages: 99
• [Journal Article] New treatment strategy for fulminant hepatitis in Japan (2010)
  • Author(s): Inoue K, Yamamura E, Sakiyama, A, Kuroda T, Yoshiba M
  • Journal Title: Hepatol Int Volume: 4 Pages: 80-81
• [Journal Article] Prediction and early intensive medical care prevented development of fulminant hepatic failure and improved survival rate (2010)
  • Author(s): Inoue K, Yamamura E, Asonuma K, Takegoshi J, Yoshiba M
  • Journal Title: Hepatol Int Volume: 4 Pages: 279
• [Journal Article] Liver support systems as perioperative care in liver transplantation-historical perspective and recent progress in Japan-Minerva Gastroenterol Dietol (2010)
  • Author(s): Inoue K, Watanabe T, Hirasawa H, Yoshiba M
  • Volume: 56
  • Pages: 345-353
• [Journal Article] Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation (2010)
  • Author(s): Inoue K, Watanabe T, Maruoka N, Kuroki Y, Takahashi H, Yoshiba M
  • Journal Title: Transplant Proc Volume: 42 Pages: 4109-4112
• [Journal Article] Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization (2010)
  • Author(s): Nuriya H, Inoue K, Tanaka T, Hayashi Y, Hishima T, Funata N, Kaji K, Hayashi S, Kaneko S, Kohara M
  • Journal Title: J Clin Microbiol Volume: 48 Pages: 3843-3851
• [Presentation] Sophistiated in situ PCR and immunohistochemistry is helpful to understand pathogenesis of chronic hepatitis and fulminant hepatitis (2011)
  • Author(s): Inoue K, Yoshiba M, Kohara M
  • Organizer: The 62nd Annual Meeting of the American Association for the Liver Diseases
  • Place of Presentation: San Francisco, U. S. A
  • Year and Date: 20110000
• [Presentation] New treatment strategy for fulminant hepatitis in Japan (2010)
  • Author(s): Inoue K, Yamamura E, Sakiyama, A, Kuroda T, Yoshiba M
  • Organizer: The 20th Conference of the APASL(The Asian Pacific Association for the Study of the Liver)
  • Place of Presentation: Beijing, China
  • Year and Date: 20100000
• [Presentation] Japanese style intensive medical care solves the shortage of organ donor and improves perioperative care of liver transplantation (2010)
  • Author(s): Inoue K, Watanabe T
  • Organizer: XXIII International Congress of The Transplantation Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20100000
• [Presentation] Originally developed intensive medical care for fulminant hepatic failure improved patients'survival rate and also safely bridge patients to liver transplantation (2010)
  • Author(s): Inoue K, Yamamura E, Watanabe T, Yoshiba M
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: New Orleans, U. S. A.
  • Year and Date: 20100000
• [Presentation] Cyclophilins are essential host factors for HCV replication (2009)
  • Author(s): Inoue K, Watanabe T, Yoshiba M, Kohara M
  • Organizer: The required level varies with HCV clone. 44th Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: Copenhagen, Norway
  • Year and Date: 20090000