The establishment of therapeutic strategy for pulmonary fibrosis and pulmonary hypertension in targeting endothelial-mesenchymal transition

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590987
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagoya University
• Principal Investigator: HASHIIMO Naozumi 名古屋大学, 医学部附属病院, 助教 (30378020)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Yoshinori 名古屋大学, 大学院・医学系研究科, 教授 (20270986) ; IMAIZUMI Kazuyoshi 藤田保健衛生大学, 大学院・医学研究科, 教授 (50362257)
• Project Period (FY): 2009 – 2011
• Keywords: 呼吸器病学

Research Abstract

Current evidence suggests that the pathogenesis of pulmonary fibrosis might be due to the heterogeneity of fibroblast origins. In this study, persistent tissue hypoxia might be involved in active fibrosis in an in vivo model of BLM-induced lung injury/fibrosis, likely due to endothelial-mesenchymal transition. These findings indicate that persistent tissue hypoxia as tissue microenvironment may promote secondary EMT and lung fibrosis. These also indicate the clue to understand the underlying mechanism of lung fibrosis, leading the new therapeutic strategy.

Research Products

• [Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells (2012)
  • Author(s): Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, KawabeT.
  • Journal Title: Biochem Biophys Res Commun Volume: 417(1) Pages: 169-174
  • Peer Reviewed
• [Journal Article] Acute exacerbation of IPF following diagnostic broncho alveolar lavage procedures (2012)
  • Author(s): Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N, Nishiyama O, Hasegawa Y.
  • Journal Title: Respir Med Pages: 436-42
  • Peer Reviewed
• [Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant CCL2 Greatly Attenuate Bleomycin-Induced Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor ofCCL2 Greatly Attenuate Bleomycin-Induced Lung Damage (2011)
  • Author(s): Saito S, Nakayama T, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T.
  • Journal Title: Am J Pathol Volume: 179(3) Pages: 1088-94
  • Peer Reviewed
• [Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells (2011)
  • Author(s): Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
  • Journal Title: Mol Carcinog
  • DOI: DOI:10.1002/mc.20802
  • Peer Reviewed
• [Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinaseandc AMP-dependent mechanisms (2011)
  • Author(s): Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
  • Journal Title: Am J Respir Cell Mol Biol Volume: 45(4) Pages: 684-91
  • Peer Reviewed
• [Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-InducedHO-1. (2011)
  • Author(s): Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.
  • Journal Title: Am J Respir Cell Mol Biol Volume: 44(5) Pages: 614-20
  • Peer Reviewed
• [Presentation] Inhibition of TGFbeta induced epithelial mesenchymal transition in lung cancer by modulation of PTEN c-terminal tail (2011)
  • Author(s): Naozumi Hashimoto
  • Organizer: 日本癌学会総会
  • Place of Presentation: 日本,名古屋
  • Year and Date: 2011-10-04
• [Presentation] Inspiratory capacity is a new preoperative risk predictor in the patients with lung cancer undergoing surgical resection European Respiratory Society Congress (2011)
  • Author(s): Naozumi Hashimoto
  • Organizer: オランダ、アムステルダム
  • Place of Presentation: アムステルダム
  • Year and Date: 2011-09-27
• [Presentation] Inhibition of Hypoxia-induced phenotype alterations through epithelial-mesenchymal transition(EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN European Respiratory Society Congress (2011)
  • Author(s): Naozumi Hashimoto
  • Organizer: オランダ、アムステルダム
  • Place of Presentation: アムステルダム
  • Year and Date: 2011-09-27
• [Presentation] A critical involvement of chronic obstructive pulmonary disease as a preo perative risk factor in the patients with lung cancer undergoing surgical resection (2011)
  • Author(s): Naozumi Hashimoto
  • Organizer: American Thoracic Society 2011
  • Place of Presentation: アメリカ、デンバー
  • Year and Date: 2011-05-17