2011 Fiscal Year Final Research Report
Investigation on the Roles of Cathepsin S in Sarcoidosis
| Project/Area Number |
21591010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
BABA Kenji 愛知医科大学, 医学部, 教授 (80211499)
TAKAHASHI Daisuke 愛知医科大学, 医学部, 助教 (00431370)
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| Project Period (FY) |
2009 – 2011
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| Keywords | サルコイドーシス・カテプシンS / アンジオテンシン転換酵素 |
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| Research Abstract |
We selected cathepsin S (CTSS) by microarray analysis of gene expression by alveolar macrophages obtained from sarcoidosis patients and compared the clinical significance of serum CTSS levels with serum activities of angiotensin converting enzyme in various diseases. We found that CTSS is superior to ACE in differentiating sarcoidosis from parenchymal lung diseases.
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