2011 Fiscal Year Final Research Report
Role of bone marrow-derived mononuclear cells on modulation of brain renin-angiotensin system
| Project/Area Number |
21591059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Akio 琉球大学, 医学部附属病院, 講師 (10343378)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高血圧学 / 中枢性血圧調節 |
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| Research Abstract |
We hypothesized that decreased number or function of bone marrow(BM)-derived cells in the brain is related to neurogenic hypertension. Intracerebroventricular(icv) administration of DiI labeled BM-derived cells revealed that a long term attachment of DiI positive cell in the brain. Although icv administration of BM-derived cells did not alter blood pressure in hypertensive rats, higher expression of angiotensin converting enzyme 2(ACE2) and Mn-SOD of the BM-derived cells and its ability to attach in the brain suggest that BM-derived cells may serve as a mobile renin-angiotensin system modulator in the brain.
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