2011 Fiscal Year Final Research Report
A novel therapeutic strategy for Parkinson's disease by activation of dopamine quinone-sensing molecules in astroglia
| Project/Area Number |
21591082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Okayama University |
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Principal Investigator |
ASANUMA Masato 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00273970)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Ikuko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40335633)
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| Project Period (FY) |
2009 – 2011
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| Keywords | パーキンソン病 / ドパミン / アストログリア / 抗酸化機構 / グルタチオン / メタロチオネイン / ドパミンキノン / 神経細胞障害 |
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| Research Abstract |
We revealed that induction and sequent release of glutathione or metallothionein in astroglia play an antioxidative protective role against neurotoxicity induced by dopamine neuron-specific oxidative stress in this study. Using neuron-astroglia coculture and parkinsonian model mice, we also proposed a possible therapeutic strategy for Parkinson's disease that a serotonin receptor agonist can protect dopamine neurons via activation of dopamine quinone-sensing molecules in astroglia.
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Research Products
(56 results)
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[Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells2011
Author(s)
Ogawa, D., Asanuma, M., Miyazaki, I., Tachibana, H., Wada, J., Sogawa, N., Sugaya, T., Kitamura, S., Maeshima, Y., Shikata, K. and Makino, F.
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Journal Title
Exp. Diabetes Res.
Volume: 2011
Pages: 534872
Peer Reviewed
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[Journal Article] Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity2011
Author(s)
Takeshima, M., Murata, M., Urasoe, N., Murakami, S., Miyazaki, I., Asanuma, M. and Kita, T.
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Journal Title
Neurol. Res.
Volume: 33
Pages: 1050-1056
Peer Reviewed
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[Journal Article] Alpha7 nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine2011
Author(s)
Ishida, S., Kawasaki, Y., Araki, H., Asanuma, M., Matsunaga, H., Sendo, T., Kawasaki, H., Gomita, Y. and Kitamura, Y.
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Journal Title
Psychopharmacology
Volume: 214
Pages: 923-931
Peer Reviewed
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[Journal Article] Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats2011
Author(s)
Kitamura, Y., Doi, M., Kuwatsuka, K., Onoue, Y., Miyazaki, I., Shinomiya, K., Koyama, T., Sendo, T., Kawasaki, H., Asanuma, M. and Gomita, Y.
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Journal Title
Biol. Pharm. Bull.
Volume: 34
Pages: 77-81
Peer Reviewed
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[Journal Article] Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity2011
Author(s)
Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., Miyoshi, K., Sogawa, N. and Kita, T.
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Journal Title
Glia
Volume: 59
Pages: 435-451
Peer Reviewed
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[Journal Article] Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats2010
Author(s)
Shinomiya, K., Matsunaga, H., Sendo, T., Kawasaki, H., Asanuma, M., Gomita, Y. and Kitamura, Y.
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Journal Title
Acta Med Okayama
Volume: 64
Pages: 219-223
Peer Reviewed
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[Journal Article] Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats2010
Author(s)
Kitamura, Y., Yagi, T., Kitagawa K., Shinomiya, K., Kawasaki H., Asanuma, M. and Gomita, Y.
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Journal Title
Naunyn-Schmied. Arch. Pharmacol.
Volume: 382
Pages: 151-158
Peer Reviewed
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[Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene2010
Author(s)
Morimoto, N., Nagai, M., Miyazaki, K., Ohta, Y., Kurata, T., Takehisa, Y., Ikeda, Y., Matsuura, T., Asanuma, M. and Abe, K.
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Journal Title
J. Neurosci. Res.
Volume: 88
Pages: 1804-1811
Peer Reviewed
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[Journal Article] Neuroprotective effects of zonisamide target astrocyte2010
Author(s)
Asanuma, M., Miyazaki, I., Diaz-Corrales, F. J., Kimoto, N., Kikkawa, Y., Takeshima, M., Miyoshi, K. and Murata, M.
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Journal Title
Ann. Neurol.
Volume: 67
Pages: 239-249
Peer Reviewed
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[Journal Article] Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice2009
Author(s)
Miyoshi, K., Kasahara, K., Miyazaki, I., Shimizu, S., Taniguchi, M., Matsuzaki, S., Tohyama, M. and Asanuma, M.
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Journal Title
FASEB J.
Volume: 23
Pages: 3289-3297
Peer Reviewed
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[Journal Article] Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice2009
Author(s)
Tanaka, K., Yagi, T., Shimakoshi, R., Azuma, K., Nanba, T., Ogo, H., Tamura, A. and Asanuma, M.
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Journal Title
Neurosci. Lett.
Volume: 462
Pages: 235-238
Peer Reviewed
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[Journal Article] Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats2009
Author(s)
Kitagawa, K., Kitamura, Y., Miyazaki, T., Miyaoka, J., Kawasaki, H., Asanuma, M., Sendo, T. and Gomita, Y.
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Journal Title
Naunyn-Schmiedebergs Arch. Pharmacol.
Volume: 380
Pages: 59-66
Peer Reviewed
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