2011 Fiscal Year Final Research Report
Functional analysis of G-protein coupled receptor 6 following brain ischemia
| Project/Area Number |
21591086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANAKA Shigeru 広島大学, 医歯薬学総合研究科, 助教 (20512651)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Masayasu 広島大学, 医歯薬学総合研究科, 教授 (20192346)
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| Project Period (FY) |
2009 – 2011
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| Keywords | GPCR |
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| Research Abstract |
G-protein coupled receptor(GPR) 3, GPR6, and GPR12 are predominantly expressed in the mammalian central nervous system and make up a subfamily of GPRs that constitutively activate adenylate cyclases. In the current study, principal investigator has clarified that expression of GPR3, GPR6, and GPR12 in rat primary neurons facilitates neuronal survival. In addition, GPR3 provides a survival advantage to cerebellar granular neurons under the hypoxic condition. Furthermore, GPR3 knockout mice exhibit a larger infarct area after transient middle cerebral artery occlusion.
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