2011 Fiscal Year Final Research Report
Research toward the development of stem cell transplantation augmented graft-versus-tumor effect against childhood malignancies
| Project/Area Number |
21591351
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 骨髄移植 / 移植片対宿主病 / IL-17 / Cytokine-induced killer細胞 |
|---|
| Research Abstract |
Cytokine-induced killer(CIK) cells exert strong graft-versus tumor effect(GVT) without causing severe acute graft-versus-host disease(GVHD) in a murine model. However, in some cases CIK cells causes mild chronic GVHD. To reduce chronic GVHD, we studied the role of IL-17, which are involved in the pathogenesis of chronic inflammation, in a murine model. We demonstrated that the mice receiving bone marrow cells from IL-17 knockout mice showed very mild chronic GVHD compared to the mice receiving wild type bone marrow cells. Bone marrow transplantation augmented GVT without causing chronic GVHD might be possible by controlling IL-17.
|
