2011 Fiscal Year Final Research Report
The etiology of food allergy and inflammatory bowel diseases in children inrelation to peptides derived from digested food proteins.
| Project/Area Number |
21591372
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Toshiaki 順天堂大学, 医学部, 教授 (30260889)
NAGATA Satoru 順天堂大学, 医学部, 准教授 (70266055)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 消化 / 食物アレルギー / 炎症性腸疾患 / 新生児・乳児消化管アレルギーリンパ濾胞 |
|---|
| Research Abstract |
To investigate the etiology of food allergy and inflammatory bowel diseases(IBD) in children in relation to peptides derived from digested food proteins, their antigenicity was analyzed ; however, no specific reactions were confirmed in serum derived from food allergy or IBD. We have also investigated the mucosal samples taken from food protein-induced proctocolitis(FPIP) and IBD with microarray, RT-PCR, immunohistochemistry and found that the lymphoid hyperplasia with eosinophilic infiltration into the colonic mucosa in response to CCL11 and CXCL13 signaling is important in FPIP while CXCL9 and CXCR3 are the key molecules in pediatric IBD.
|
-
-
-
[Journal Article] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms2011
Author(s)
Nomura I, Morita H, Hosokawa S, Hoshina H, Fukuie T, Watanabe M, Ohtsuka Y, Shoda T, Terada A, Takamasu T, Arai K, Ito Y, Ohya Y, Saito H, Matsumoto K.
-
Journal Title
J Allergy Clin Immunol
Volume: 127
Pages: 685-688
Peer Reviewed
-
-
[Journal Article] Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease2010
Author(s)
Ohtsuka Y, Arai K, Aoyagi Y, Fujii T, Yamakawa Y, Ohtani K, Ikuse T, Baba Y, Inage E, Kudo T, Suzuki R, Nagata S, Shimizu T.
-
Journal Title
J Gastroenterol Hepatol
Volume: 25
Pages: 1626-30
Peer Reviewed
-
-
-
-
-
-
[Journal Article] 新生児・乳児消化管アレルギーの病態消化管局所における病態2009
Author(s)
大塚宜一, 馬場洋介, 幾瀬圭, 山川陽子, 藤井徹, 青柳陽, 東海林宏道, 工藤孝広, 鈴木竜洋, 佐藤洋明, 清水俊明
-
Journal Title
日本小児アレルギー学会雑誌
Volume: 23
Pages: 18-24
Peer Reviewed
-
-
[Presentation] 新生児乳児消化管アレルギー患児の粘膜を用いた病態の解析2011
Author(s)
大塚宜一, 石田明日香, 神保圭祐, 稲毛英介, 馬場洋介, 森真理, 山川陽子, 和田万里子, 工藤孝広, 鈴木竜洋, 清水俊明
Organizer
第61回日本アレルギー学会秋季大会ミニシンポジウム
Place of Presentation
グランドプリンスホテル新高輪(東京)
Year and Date
2011-11-12
-
-
-
-
-
-
-
-
-
[Presentation] Microarrayを用いた小児期炎症性腸疾患の病態の検討2010
Author(s)
大塚宜一, 櫻井由美子, 藤武義人, 稲毛英介, 幾瀬圭, 馬場洋介, 鈴木光幸, 青柳陽, 藤井徹, 工藤孝広, 清水俊明
Organizer
第37回日本小児栄養消化器肝臓学会
Place of Presentation
かがわ国際会議場(高松)
Year and Date
20101009-10
-
-
-
-
-
-
[Presentation] 仔ラット消化管粘膜におけるprobioticsの抗炎症効果について2009
Author(s)
大塚宜一, 藤井徹, 鈴木竜洋, 永田智, 和泉裕久, 名村真理子, 峯岸真梨緒, 稲毛英介, 山川陽子, 松原知代, 清水俊明
Organizer
第46回日本小児アレルギー学会
Place of Presentation
福岡国際会議場(福岡)
Year and Date
2009-12-06
-
-
[Presentation] Microarrayを用いた仔ラット消化管粘膜に与えるprobioticsの効果の検討2009
Author(s)
大塚宜一, 櫻井由美子, 和泉裕久, 名村真理子, 峯岸真梨緒, 馬場洋介, 幾瀬圭, 藤井徹, 鈴木竜洋, 永田智, 稲毛英介, 山川陽子, 松原知代, 清水俊明
Organizer
第59回日本アレルギー学会秋季学術大会ミニシンポジウム
Place of Presentation
秋田ビューホテル(秋田)
Year and Date
2009-10-31
-
[Presentation] B. breveの仔ラット消化管粘膜に与える効果について2009
Author(s)
大塚宜一, 和泉裕久, 名村真理子, 峯岸真梨緒, 馬場洋介, 幾瀬圭, 稲毛英介, 大谷清孝, 山川陽子, 青柳陽, 藤井徹, 工藤孝広, 東海林宏道, 鈴木竜洋, 永田智, 清水俊明
Organizer
第36回日本小児栄養消化器肝臓学会
Place of Presentation
北海道大学学術交流会館(札幌)
Year and Date
2009-10-10
-
-
-
-
-
-
-
-
-
-
-
