The development of mechanism and new therapy of the pruritis of atopic dermatitis.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagasaki University
• Principal Investigator: TAKENAKA Motoi 長崎大学, 病院, 講師 (30281207)
• Co-Investigator(Kenkyū-buntansha): SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792) ; BAE Sangjae 長崎大学, 病院, 医員 (90325647)
• Project Period (FY): 2009 – 2011
• Keywords: アトピー性皮膚炎 / 神経ペプチド / サブスタンスP / neutral endopeptidase

Research Abstract

Substance P is released from the sensory nerve of the skin, and it is known that substance P induce the inflammation of the skin. In the patient with the atopic dermatitis, when blood substance P was measured, substance P decreased by the standard treatment, and the m-RNA expression of degrading enzyme of substance P was enhanced. And, in the mouse which gave the stress, the contact hypersensitivity reaction enhanced, and L-selectin and substance P was indicated in the mechanism of enhanced response by the stress.

Research Products

• [Journal Article] A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients wuth syatemic sclerosis (2011)
  • Author(s): Muroi E, Hara T, Yanaba K, Ogawa F, Yoshizaki A, Takenaka M, Shimizu K, Sato S
  • Journal Title: Rheumatol Int Volume: 31(12) Pages: 1601-1606
  • Peer Reviewed
• [Journal Article] Elevated serum interleukin-27 levels in patients with systemic sclerosis : association with T cell, B cell and fibroblast activation (2011)
  • Author(s): Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Muroi E, Ogawa F, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: Ann Rheum Dis Volume: 70(1) Pages: 194-200
  • Peer Reviewed
• [Journal Article] Rhizomucor variabilis infection in human cutaneous mucormycosis (2011)
  • Author(s): Tomita H, Muroi E, Takenaka M, Nishimoto K, Kakeya H, Ohno H, Miyazaki Y, Utani A
  • Journal Title: Clin Exp Dermatol Volume: 36(3) Pages: 312-314
  • Peer Reviewed
• [Journal Article] The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis (2011)
  • Author(s): Yoshizaki A, Yanaba K, Ogawa A, Iwata Y, Ogawa F, Takenaka M, Shimizu K, Asano Y, Kadono T, Sato S
  • Journal Title: Arthritis Rheum Volume: 63(10) Pages: 3086-3097
  • Peer Reviewed
• [Journal Article] Involvement of L-selectin in contact hypersensitivity responses augmented by auditory stress (2010)
  • Author(s): Bae SJ, Shimizu K, Yozaki M, Yamaoka T, Akiyama Y, Yoshizaki A, Muroi E, Hara T, Ogawa F, Sato S
  • Journal Title: Am J Pathol Volume: 176(1) Pages: 187-197
  • Peer Reviewed
• [Journal Article] The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity (2010)
  • Author(s): Ogawa A, Yoshizaki A, Yanaba K, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S
  • Journal Title: J Invest Dermatol Volume: 130(6) Pages: 1558-1570
  • Peer Reviewed
• [Journal Article] Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis (2010)
  • Author(s): Okazaki S, Ogawa F, Iwata Y, Hara T, Muroi E, Komura K, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: Rheumatol Int Volume: 30(7) Pages: 871-878
  • Peer Reviewed
• [Journal Article] Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction (2010)
  • Author(s): Hara T, Shimizu K, Ogawa F, Yanaba K, Iwata Y, Muroi E, Takenaka M, komura K, Sato S
  • Journal Title: Am J Pathol Volume: 176(1) Pages: 259-269
  • Peer Reviewed
• [Journal Article] Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis : Association with pulmonary fibrosis and vascular damage (2010)
  • Author(s): Ogawa F, Shimizu K, Hara T, Muroi E, Komura K, Takenaka M, Hasegawa M, Fujimoto M, Takehara K, Sato S
  • Journal Title: Arch Dermatol Res Volume: 302(1) Pages: 27-35
  • Peer Reviewed
• [Journal Article] Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis : Association with severity of pulmonary fibrosis (2010)
  • Author(s): Tomita H, Ogawa F, Hara T, Yanaba K, Iwata Y, Muroi E, Yoshizaki A, Komura K, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: J Rheumatol Volume: 37(4) Pages: 787-791
  • Peer Reviewed
• [Journal Article] Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis (2010)
  • Author(s): Yoshizaki A, Yanaba K, Yoshizaki As, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: Arthritis Rheum Volume: 62(8) Pages: 2476-2487
  • Peer Reviewed
• [Journal Article] Autoantibody against survivin in patients with systemic sclerosis (2010)
  • Author(s): Koike Y, Muroi E, Yoshizaki A, Ogawa F, Yanaba K, Takenaka M, Shimizu K, Sato S
  • Journal Title: J Rheumatol Volume: 37(9) Pages: 1864-1870
  • Peer Reviewed
• [Journal Article] Cell adhesion molecules regulate fibrotic process via Th1/ Th2/ Th17 cell balance in a bleomycin-induced scleroderma model (2010)
  • Author(s): Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y, Muroi E, Hara T, Ogawa F, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, T fF Tedder, Sato S
  • Journal Title: J Immunol Volume: 185(4) Pages: 2502-2515
  • Peer Reviewed
• [Journal Article] Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis : association with disease severity (2009)
  • Author(s): Yoshizaki A, Komura K, Iwata Y, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: J Clin Immunol Volume: 29(2) Pages: 180-189
  • Peer Reviewed
• [Journal Article] Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis (2009)
  • Author(s): Kuwatsuka Y, Ogawa F, Iwata Y, Komura K, Muroi E, Hara T, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: Autoimmunity Volume: 42(2) Pages: 120-125
  • Peer Reviewed
• [Journal Article] Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis : association with pulmonary fibrosis (2009)
  • Author(s): Hara T, Ogawa F, Yanaba K, Iwata Y, Muroi E, Komura K, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: J Rheumatol Volume: 36(1) Pages: 99-105
  • Peer Reviewed
• [Journal Article] Increased serum pentraxin 3 in patients with systemic sclerosis (2009)
  • Author(s): Iwata Y, Yoshizaki A, Ogawa F, Komura K, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Takehara K, Sato S
  • Journal Title: J Rheumatol Volume: 36(5) Pages: 976-983
  • Peer Reviewed
• [Journal Article] Autoantibody against activating transcription factor-2 in patients with systemic sclerosis (2009)
  • Author(s): Akiyama Y, Ogawa F, Iwata Y, Komura K, Hara T, Muroi E, Bae SJ, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: Clin Exp Rheumatol Volume: 27(5) Pages: 751-757
  • Peer Reviewed
• [Journal Article] CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling (2009)
  • Author(s): Iwata Y, Yoshizaki A, Komura K, Shimizu K, Ogawa F, Hara T, Muroi E, Bae SJ, Takenaka M, Yukami T, Hasegawa M, Fujimoto M, Tomita Y, Tedder TF, Sato S
  • Journal Title: Am J Pathol Volume: 175(2) Pages: 649-660
  • Peer Reviewed
• [Journal Article] P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand (2009)
  • Author(s): Tomita H, Iwata Y, Ogawa F, Komura K, Shimizu K, Yoshizaki A, Hara T, Muroi E, Yanaba K, Bae SJ, Takenaka M, Hasegawa M, Fujimoto M, Sato S
  • Journal Title: J Invest Dermatol Volume: 129(8) Pages: 2059-2067
  • Peer Reviewed