2011 Fiscal Year Final Research Report
Involvement of selectins and their ligands in wound healing
| Project/Area Number |
21591469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Shinichi 東京大学, 医学部附属病院, 教授 (20215792)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Fumihide 長崎大学, 医学部・歯学部付属病院, 講師 (10333519)
YOSHIZAKI Ayumu 長崎大学, 医学部・歯学部付属病院, 講師 (40530415)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞接着分子 / PSGL-1 / P-selectin / 創傷治癒 |
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| Research Abstract |
Cell adhesion molecules are critical to wound healing through leukocyte recruitment. To clarify a role of P-selectin glycoprotein ligand-1(PSGL-1), one of cell adhesion molecules, in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient mice. The results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells.
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