2011 Fiscal Year Final Research Report
Association study of promoter polymorphisms in the dopamine-beta-hydroxylase gene and the dopamine transporter gene with personality traits in healthy subjects
| Project/Area Number |
21591480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTANI Koichi 山形大学, 医学部, 教授 (00194192)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 性格傾向 / ドパミントランスポーター / ドパミンβ水酸化酵素(DBH) / TCI |
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| Research Abstract |
In this study, we investigated the association of polymorphisms of the dopamine-beta-hydroxylase (DBH) and the dopamine transporter (DAT) with personality traits in healthy Japanese. Personality traits were assessed by Temperament and Character Inventory (TCI), and PCR-RFLP method was used. With regard to the DAT, the females without the A allele of the-67A/T promoter polymorphism had lower scores of self-directedness and cooperativeness than those with the A allele. The intron VNTR polymorphism did not affect any TCI score. Regarding the DBH, the females with the T allele of the-1021C/T promoter polymorphism had higher scores of harm avoidance than those without T allele. The present results suggest that those polymorphisms of the DAT and DBH genes affect personality traits in healthy subjects.
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