2011 Fiscal Year Final Research Report

Development of novel production method of high purity lutetium-177 for advanced cancer therapy

Research Project

Project/Area Number	21591586
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	Japan Atomic Energy Agency
Principal Investigator	WATANABE Satoshi 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 (40354964)
Project Period (FY)	2009 – 2011
Keywords	ルテチウム-177 / 分離精製法 / イミノ二酢酸キレート樹脂
Research Abstract	Lutetium-177 is considered to have potential for application in radionuclide therapy, because it emits b-particles suitable to penetrate small tumors. In addition, real time imaging of biodistribution can be done by using the ^<177>Lu, because the energy of g-rays emitted from ^<177>Lu is particularly suitable for imaging by single photon emission computed tomography. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added ^<177>Lu produced in the ^<176>Yb(n, g) ^<177>Yb → ^<177>Lu process are desired. In this production, separation of ^<177>Lu from Yb target is required. Therefore, in the present paper, basic study of separation between Lu and Yb by using iminodiacetic acid chelating resin is investigated. It was found that the best separation between Lu and Yb was achieved by using 0.013 M HNO_3 for the eluent and the column of 4.6 mmφｘ450 mm size.

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