2011 Fiscal Year Final Research Report
Development of novel molecular targeted therapeutics that target the hypoxic environment of solid tumors
| Project/Area Number |
21591678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍選択的治療 / 嫌気性菌ベクター / ラクトバチルス |
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| Research Abstract |
Systemic administration of anticancer drugs may have serious side effects, and development of tumor-selective therapy is urgently needed. We investigated the clustering and antiproliferative effects of Lactobacillus casei, a lactobacillus, on solid tumors, based on the inside of a solid tumor being an aerobic environment compared with normal tissues. Bacterial strain KJ686, an obligate anaerobe, specifically clustered in solid tumors, but was eliminated from normal tissues. This strain may be useful as a tumor-selective delivery system that may have high therapeutic efficacy.
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Research Products
(9 results)
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[Journal Article] CSLEX(Sialy Lewis X) is a useful tumor marker for monitoring of breast cancer patients2011
Author(s)
Fujita T, Murayama K, Hanamura T, Okada T, Ito T, Harada M, Komatsu A, Koyama H, Kanai T, Maeno K, Mochizuki Y, Hama Y, Ito K, Amano J, Fujimori M
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Journal Title
Jpn J Clin Oncol
Volume: 41巻
Pages: 394-399
DOI
Peer Reviewed
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