2011 Fiscal Year Final Research Report
Chemoprevention for Barrett's esophageal adenocarcinogenesis by inhibiting bile acid receptor, FXR.
| Project/Area Number |
21591695
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 十二指腸食道逆流 / 食道腺癌 / Farnesoid X receptor(FXR) / ガグルステロン / Cyclooxygenase-2(COX-2) |
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| Research Abstract |
We examined chemopreventive effect of gugglesterone(GS), an antagonist of farnesoid X receptor, on Barrett's esophageal cancer using rodent duodenoesophageal reflux model. Animals were divided into 3 groups, high GS group, low GS group and control and sacrificed 20, 40, 50 weeks after operation. There were no significant differences between 3 groups in the incidences of hyperplasia, columnar epithelia, dysplasia, and carcinoma in all terms. These results suggested that GS had no preventive effect on the esophagocarcinogenesis in this model.
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