2011 Fiscal Year Final Research Report
Research of the characteristics of disseminated gastric cancer cells and the factors of sensitivity and tolerance to chemotherapeutic agents.
| Project/Area Number |
21591713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURAMOCHI Hidekazu 東京女子医科大学, 医学部, 助教 (30287362)
KAMIKODURU Hirotaka 東京女子医科大学, 医学部, 助教 (40328430)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 十二指腸外科学 / 胃癌 / 腹膜播種 |
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| Research Abstract |
We planned the drug sensitivity test using gastric cancer cell line knocked down Osteopontin(OPN), however it did not work well. We next tried this work with colon cancer cell line. The colon cancer cell line which is knocked OPN down with specific siRNA has required 5FU resistance compared to control cell line. The difference was not observed when docetaxel was exposed.
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