2011 Fiscal Year Final Research Report

Development of cancer stem cell vaccine therapy based on the Niche theory

Research Project

Project/Area Number	21591729
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Wakayama Medical University
Principal Investigator	MATSUDA Kenji 和歌山県立医科大学, 医学部, 助教 (30398458)
Co-Investigator(Kenkyū-buntansha)	YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190) IWAHASHI Makoto 和歌山県立医科大学, 医学部, 准教授 (70244738) HOTTA Tsukasa 和歌山県立医科大学, 医学部, 講師 (50244744) NAKUMURA Masaki 和歌山県立医科大学, 医学部, 講師 (80364090) OJIMA Toshiyasu 和歌山県立医科大学, 医学部, 助教 (60448785) KATSUDA Masahiro 和歌山県立医科大学, 医学部, 助教 (50464673)
Project Period (FY)	2009 – 2011
Keywords	癌幹細胞 / Niche / WT1
Research Abstract	We assessed immunoresponse to WT1 protein to develop cancer stem cell vaccine therapy. WT1 protein have a potential power to maintain the malignancies of its cancer cell, and it is expressed several malignancies. We confirmed HLA-A24 restricted WT1 derived peptide specific immunoresponses. Furthermore, we tried to separate cancer stem cell by using CD133 antibody. We confirmed the spheres formation in some parts of cancer cell. We believe that this may be consolidated the foundation of Niche control.