2011 Fiscal Year Final Research Report
The coadministration of granulocyte colony-stimulating factor and stem cell factor to secondary injury after spinal cord injury(Analysis of endplasmic reticulum stress response)
| Project/Area Number |
21591907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUYAMA Kaori 東海大学, 医学部, 助教 (20433914)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脊椎脊髄病学 |
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| Research Abstract |
In this study, We focused on endoplasmic reticulum(ER) stress as a cause of apoptosis of oligodendrocyte precursor cell(OPC) following spinal cord injury, and examined it in vivo, and in vitro. In addition, We investigated the effects of G-CSF and SCF on intrinsic cells, and motor function recovery in spinal cord-injured mice. The results showed that the combined administration of SCF and G-CSF in mouse contusive spinal cord injury model not only improved motor function, but also induced the accumulation of intrinsic microglia and the active proliferation of intrinsic OPC. Our results suggest that apoptosis by the ER stress is involved in the differential inhibition of OPC, and To increase the tolerance of ER stress response of OPC may result in remyelination of damaged spinal cord.
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