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2011 Fiscal Year Final Research Report

Function of a new aquaporin in the brain edema.

Research Project

  • PDF
Project/Area Number 21591983
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya City University

Principal Investigator

SOBUE Kazuya  名古屋市立大学, 大学院・医学研究科, 教授 (90264738)

Co-Investigator(Kenkyū-buntansha) ASAI Kiyofumi  名古屋市立大学, 大学院・医学研究科, 教授 (70212462)
SUGIURA Takeshi  名古屋市立大学, 大学院・医学研究科, 講師 (20295611)
Project Period (FY) 2009 – 2011
Keywords水チャネル / 中枢神経 / 発現調節
Research Abstract

The membrane pore proteins, aquaporins(AQPs), facilitate the osmotically driven passage of water and, in some instances, small solutes. AQP4 plays important roles in maintaining brain homeostasis and formation of brain edema. However, little is known about function of AQP9 in brain edema. The expression of AQP9 is regulated by the p38 MAPK pathway. Hypoxia evoked a marked decrease in the expression levels of AQP9 and in astrocytes in vitro subsequent reoxygenation elicited the restoration of the expression of AQP9 to their basal levels. These results suggest that AQP9 may be one of the candidates for inducing the intracranial edema in the CNS after ischemia injury.

  • Research Products

    (3 results)

All 2011 2010

All Journal Article (2 results) Presentation (1 results)

  • [Journal Article] Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras(ERas) signal in neuroblastoma cells2011

    • Author(s)
      Aoyama M, Kataoka H, Kubota E, Tada T, Asai K
    • Journal Title

      Int J Oncol

      Volume: 37 Pages: 1011-6

  • [Journal Article] 水チャネル<アクアポリン>の中枢神経における多様な機能と関連疾患2010

    • Author(s)
      祖父江和哉他
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 38 Pages: 145-50

  • [Presentation] 敗血症におけるastrocyteでのHIF(hypoxia inducing factor)-1の役割2010

    • Author(s)
      高柳猛彦、祖父江和哉、他
    • Organizer
      第37回日本集中治療医学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-05

URL: 

Published: 2013-07-31  

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