2011 Fiscal Year Final Research Report
Regulation for niche formation of cancer stem cells by carcinoma-associated fibroblasts in prostate tumor
| Project/Area Number |
21592039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Mie University |
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Principal Investigator |
ARIMA Kiminobu 三重大学, 大学院・医学系研究科, 准教授 (10175995)
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| Co-Investigator(Kenkyū-buntansha) |
SOGA Norihito 三重大学, 医学部附属病院, 講師 (60332714)
ISHII Kenichiro 三重大学, 大学院・医学系研究科, 助教 (90397513)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 前立腺癌幹細胞 / 癌間質 / 線維芽細胞 / 初代培養 / 共培養 / TGFβ1 |
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| Research Abstract |
In the tumor microenvironment, carcinoma-associated fibroblasts(CAF_s) are considered to play a critical role in the niche formation of cancer stem cells. To understand how CAF_s are generated during primary cancer progression, we investigated the biochemical characteristics of normal human prostate stromal cells(P_rSC) co-cultured with human prostate cancer(PC_a) cells in vitro. Our results have demonstrated that normal fibroblasts co-cultured with cancer cells become activated and exhibit biochemical characteristics of CAF_s in a heterogenous manner. Finally, we suggest that heterogenous induction of CAF_s-like differentiation might be strongly dependent on biochemical characteristics of adjacent cancer cells.
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Research Products
(53 results)
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[Journal Article] Naftopidil, a subtype selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011
Author(s)
Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
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Journal Title
Cancer Prevention Research
Volume: 4
Pages: 87-96
Peer Reviewed
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[Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer
Author(s)
Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
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Journal Title
Urologic Oncology(in press)
Peer Reviewed
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[Presentation] Biological effects of fetal exposure to bisphenol A on urogenital sinus2010
Author(s)
Kenichiro Ishii, Shigeki Arase, Yuko Yoshio, Katsuhide Igarashi, Kenichi Aisaki, Yasuhide Hori, Kohei Nishikawa, Norihito Soga, Hideaki Kise, Kiminobu Arima, Jun Kanno, Yoshiki Sugimura
Organizer
The 2010 American Urological Association(AUA) Annual Meeting
Place of Presentation
San Francisco
Year and Date
20100528-0603
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[Presentation] Biological effects of fetal exposure to bisphenol A on urogenital sinus2009
Author(s)
Kenichiro Ishii, Shigeki Arase, Katsuhide Igarashi, Kenichi Aisaki, Yuko Yoshio, Yasuhide Hori, Kohei Nishikawa, Norihito Soga, Hideaki Kise, Kiminobu Arima, Jun Kanno, Yoshiki Sugimura
Organizer
19th Annual Fall Meeting of the Society for Basic Urologic Research
Place of Presentation
New Orleans
Year and Date
20091105-08
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