2011 Fiscal Year Final Research Report
Mechanism of tumor regulation by galactose-binding protein in hormone refractory prostate cancer
| Project/Area Number |
21592048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Hiro-omi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10214446)
MASAYUKI Takahashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50325255)
NAKATSUJI Hiroyoshi 徳島大学, 病院, 助教 (50437638)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 前立腺癌 / ガレクチンー3 / ホルモン不応性 / ホルモン受容体 / 遺伝子治療 |
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| Research Abstract |
Galectin-3, has been strongly expressed in hormone-refractory prostate cancer, showed a negative correlation between expression of androgen receptor and galectin-3 in hormone-refractory prostate cancer cell line PC3. Galectin-3 was involved in resistance to apoptosis induced by platinum-based drug and radio therapy through the suppression of the caspase-3 activity and stability of the mitochondria. Galectin-3 is a target protein involved in the resistance of hormone therapy, chemotherapy and radiotherapy in hormone-refractory prostate cancer.
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