2011 Fiscal Year Final Research Report
The role of adiponectin and resistin in the pathogenesis of postmenopausal metabolic syndrome
| Project/Area Number |
21592142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SATOH Hiroaki 福島県立医科大学, 医学部, 准教授 (20323595)
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| Co-Investigator(Kenkyū-buntansha) |
MIDORIKAWA Sanae 福島県立医科大学, 医学部, 講師 (10325962)
WATANABE Tsuyoshi 福島県立医科大学, 医学部, 講師 (80158641)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 更年期医学 / インスリン抵抗性 / アディポサイトカイン |
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| Research Abstract |
To investigate the physiological role of Adipo and Res in the postmenopausal, estrogen-deficient state, we studied the chronic in vivo effect of Adipo and Res on insulin sensitivity in young ovariectomized female Wistar rats. Estrogen-deficient state had significantly increased body weight and decreased insulin sensitivity. Adiponectin improves the estrogen deficiency induced insulin resistance, whereas resistin exacerbates the estrogen deficiency induced insulin resistance. Furthermore, we found that AMPK is a key molecule player in muscle and liver.
These results that the insulin resistance has been involved in the incidence of diabetes increases as women age, especially after menopause.
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[Presentation] The High Potassium Intake Improves High Fat Diet Induced Insulin Resistance in Male Wistar Rats.2011
Author(s)
Satoh H, Sugaya Y, Kudoh A, Yamazaki S, Machii N, Watanabe S, Hirai H, Hasegawa K, Nakajima S, Midorikawa S, Watanabe T.
Organizer
71^<st> American Diabetes Association Scientific Sessions
Place of Presentation
San Diego CA
Year and Date
20110624-28
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[Presentation] Impairment of insulin sensitivity via reactive oxygen species in muscle cells2010
Author(s)
Kudoh A, Satoh H, Hirai H, Yamazaki S, Sugaya Y, Machii N, Hasegawa K, Watanabe S, Nakajima S, Midorikawa S, Watanabe T.
Organizer
第42回日本動脈硬化学会総会・学術集会
Place of Presentation
岐阜県岐阜市
Year and Date
20100715-16
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[Presentation] Amenorrhea resulting from polycystic ovary syndrome(PCOS) secondary to growth hormone(GH) producing pituitary adenoma2010
Author(s)
Watanabe S, Midorikawa S, Sugaya Y, Honma M, Machii N, Hirai H, Kudoh A, Hasegawa K, Fujiwara F, Nakajima N, Satoh H, Watanabe T.
Organizer
14^<th> International Congress of Endocrinology(ICE2010)
Place of Presentation
Kyoto
Year and Date
20100326-30
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[Presentation] Comparison two kinds of PPAR_γ agonist, pioglitazone or telmisartan, on circulating total adiponectin and its multimer distribution in patients with type 2 diabetes2010
Author(s)
Satoh H, Kudoh K, Hirai H, Yamazaki S, Hasegawa K, Fujiwara F, Watanabe S, Sugaya Y, Machii N, Honma M, Nakajima S, Midorikawa S, Watanabe T
Organizer
14^<th> International Congress of Endocrinology(ICE2010)
Place of Presentation
Kyoto, JAPAN
Year and Date
20100326-30
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[Presentation] The Mechanisms by which Pioglitazone Improves Insulin Sensitivity and Increases Body Weight in Patients with Type 2 Diabetes Mellitus2009
Author(s)
Hirai H, Satoh H, Kudoh A, Hasegawa K, Yamazaki S, Sugaya Y, Fujiwara M, Honma M, Nakajima S, Midorikawa S, Watanabe T
Organizer
69^<th> American Diabetes Association Scientific Sessions
Place of Presentation
New Orleans, LA
Year and Date
20090605-09
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[Presentation] Adenovirus-mediated chronic expression of adiponectin improves early stage diabetic nephropathy in STZ induced diabetic Wistar rats2009
Author(s)
Satoh H, Nakamaki S, Kudoh A, Hirai H, Yamazaki S, Sugaya Y, Hasegawa K, Fujiwara M, Honma M, Nakajima S, Midorikawa S, Watanabe T
Organizer
69^<th> American Diabetes Association Scientific Sessions
Place of Presentation
New Orleans, LA
Year and Date
20090605-09
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