Objective olfactory function test with olfactory nerve transport

2012 Fiscal Year Final Research Report

• Project/Area Number: 21592174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa Medical University
• Principal Investigator: SHIGA Hideaki 金沢医科大学, 医学部, 講師 (80436823)
• Co-Investigator(Kenkyū-buntansha): MIWA Takaki 金沢医科大学, 医学部, 教授 (20229909) ; NAKANISHI Sayaka 金沢大学, 附属病院, 助教 (40532180)
• Co-Investigator(Renkei-kenkyūsha): TAKI Jyunchi 金沢大学, 附属病院, 臨床教授 (10251927) ; KINUYA Seigo 金沢大学, 医学系, 教授 (20281024)
• Project Period (FY): 2009 – 2012
• Keywords: 嗅覚障害 / 分子イメージング

Research Abstract

Wecassessedcperipheralcolfactorycnervectransportcfunctionzcbycperformingccombinedcsinglecphotoncemissionccomputedctomographyc(SPECT)andcmagneticcresonancecimagingc(MRI)caftercnasalcadministrationcofcthallium-201c(201Tl)ctocdeterminecwhethercolfactorycnervectransportcfunctioncwascreducedcincpatientscwithcolfactorycimpairmentscinccomparisonctochealthycvolunteers.cNasalc201Tlcolfactoryctransportcwascsignificantlyclowercincthecpatientscwithcheadctrauma,crespiratorycinfection,candcchroniccrhinosinusitiscthancinchealthycvolunteers.cFurthermore,cnasalc201TlcolfactoryctransportcwascsignificantlyccorrelatedcwithcodorcrecognitioncthresholdcandcodorcdetectioncthresholdcbycT&Tcolfactometrycincthechealthycvolunteerscandcthecolfaction-impairedcpatientscevaluatedcascacsinglecgroup.cNocsubjectscexperiencedcanycadversecevents.

Research Products

• [Journal Article] Assessment of olfactory nerve bySPECT-MRI image with nasalthallium-201 administration inpatients with olfactory impairmentsin comparison to healthy volunteers. (2013)
  • Author(s): Shiga, H., Taki, J., Washiyama, K., 他10名
  • Journal Title: PLoS ONE Volume: 8(2) Pages: e57671
  • DOI: DOI:10.1371/journal.pone.0057671.
  • Peer Reviewed
• [Journal Article] 嗅球除去によるインスリン様成長因子-I脳内輸送の低下 (2013)
  • Author(s): 志賀英明, 長岡三樹矢, 鷲山幸信
  • Journal Title: 耳鼻咽喉科ニューロサイエンス Volume: 27 Pages: 62-64
• [Journal Article] Internal dosimetryfor nasal thallium-201 administration. (2012)
  • Author(s): Kinase, S., Washiyama, K., Shiga, H.
  • Journal Title: KEK Proceedings Volume: 7 Pages: 35-40
• [Journal Article] 副鼻腔炎による嗅覚障害に対する鼻内内視鏡手術の工夫中鼻甲介開窓術- (2012)
  • Author(s): 三輪高喜, 山田奏子, 山本純平, 木下裕子, 志賀英明
  • Journal Title: 耳鼻咽喉科展望 Volume: 55 Pages: 376-379
• [Journal Article] 末梢嗅神経を介した脳内への微小粒子の輸送-嗅覚障害における課題- (2012)
  • Author(s): 志賀英明, 山本純平, 三輪高喜
  • Journal Title: 耳鼻咽喉科展望 Volume: 55 (補1) Pages: 15-19
• [Journal Article] 嗅神経輸送機能の臨床診断 (2012)
  • Author(s): 志賀英明, 山本純平, 三輪高喜
  • Journal Title: 薬学雑誌 Volume: 132(11) Pages: 1263-1266
• [Journal Article] 鼻腔内の腫れ:腫れをみたとき考えること -鑑別疾患とピットフォール- (2012)
  • Author(s): 志賀英明, 三輪高喜
  • Journal Title: JOHNS Volume: 28(7) Pages: 1011-1014
• [Journal Article] 副鼻腔疾患と頭痛 (2012)
  • Author(s): 志賀英明, 三輪高喜
  • Journal Title: MB ENT Volume: 137 Pages: 35-38
• [Journal Article] 嗅神経トランスポートとインスリン様成長因子-Iの脳内輸送 (2012)
  • Author(s): 志賀英明, 山本純平, 三輪高喜
  • Journal Title: 頭頸部自律神経 Volume: 26 Pages: 61-63
• [Journal Article] 薬剤性障害モデルにおける漢方製剤の嗅神経保護作用 -神経成長因子との関連- (2012)
  • Author(s): 山本純平, 志賀英明, 鷲山幸信, 天野良平, 三輪高喜
  • Journal Title: 頭頸部自律神経 Volume: 26 Pages: 57-60
• [Journal Article] 静脈性嗅覚検査・希釈法の有用性に関する検討 (2012)
  • Author(s): 小林正佳, 三輪高喜,志賀英明
  • Journal Title: 日本鼻科学会誌 Volume: 51(4) Pages: 445-449
  • Peer Reviewed
• [Journal Article] Biologicalsafety of nasal thallium-201administration : a preclinical studyfor olfacto-scintigraphy. (2011)
  • Author(s): Washiyama, K., Shiga, H., Hirota, K.
  • Journal Title: J.Radiation Research Volume: 52(4) Pages: 450-455
  • DOI: DOI:10.1269/jrr.10153
  • Peer Reviewed
• [Journal Article] Evaluationof the olfactory nerve transportfunction by SPECT-MRI fusion imagewith nasal thallium-201administration. (2011)
  • Author(s): Shiga, H., Taki, J., Yamada, M.
  • Journal Title: Molecular Imaging and Biology Volume: 13(6) Pages: 1262-1266
  • DOI: DOI:10.1007/s11307-010-0461-3
  • Peer Reviewed
• [Journal Article] 嗅神経画像評価のための201Tlオルファクトシンチグラィの試み (2010)
  • Author(s): 三輪高喜, 志賀英明,山本純平
  • Journal Title: 頭頸部自律神経 Volume: 24 Pages: 40-43
• [Journal Article] 漢方薬の取り入れ方のコツ 嗅覚障害 (2010)
  • Author(s): 志賀英明, 三輪高喜
  • Journal Title: JOHNS Volume: 26(4) Pages: 592-594
• [Journal Article] 嗅神経再生診断における分子イメージングの応用 (2010)
  • Author(s): 志賀英明, 三輪高喜
  • Journal Title: 日本鼻科学会誌 Volume: 49(1) Pages: 72-73
• [Journal Article] 嗅覚同定機能測定装置 (2010)
  • Author(s): 三輪高喜, 志賀英明, 小早川達, 斉藤幸子
  • Journal Title: JOHNS Volume: 26(6) Pages: 855-858
• [Journal Article] 簡易な嗅覚評価のための「日常のにおいアンケート (2009)
  • Author(s): 都築建三, 三輪高喜,志賀英明
  • Journal Title: 日本鼻科学会誌 Volume: 48 (1) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Usefulness of curry odoran of odor stick identification test forJapanese in olfactory impairmentscreening. (2009)
  • Author(s): Shiga, H., Miwa, T
  • Journal Title: Acta Otolaryngologica Volume: 129(Suppl 562) Pages: 91-94
  • Peer Reviewed
• [Journal Article] Useof thallium transport to visualize functional olfactory nerveregeneration in vivo. (2009)
  • Author(s): Shiga, H., Washiyama, K., Hirota, K., Amano R., Furukawa, M., Miwa, T.
  • Journal Title: Rhinology Volume: 47 Pages: 460-464
  • DOI: DOI:10.4193/Rhin08.213.
  • Peer Reviewed
• [Journal Article] SPECT/CTによるラット嗅神経の画像評価 (2009)
  • Author(s): 志賀英明,三輪高喜
  • Journal Title: 日本鼻科学会誌 Volume: 48 (2) Pages: 138-141
  • Peer Reviewed
• [Journal Article] 外来化学療法における嗅覚の変化. (2009)
  • Author(s): 志賀英明, 川岸篤史, 宮本謙一, 笠原寿郎, 三輪高喜
  • Journal Title: 日本味と匂学会誌 Volume: 16(3) Pages: 653-654
  • Peer Reviewed
• [Journal Article] 嗅覚障害に対するアイソトープを用いた機能的画像診断 (2009)
  • Author(s): 三輪高喜, 志賀英明, 木下弥生, 広田京子, 土田明日香, 古川仭
  • Journal Title: 日本鼻科学会誌 Volume: 48(1) Pages: 82-84
• [Journal Article] 嗅神経再生と分子イメージング (2009)
  • Author(s): 志賀英明, 三輪高喜.
  • Journal Title: 日本味と匂誌 Volume: 16(1) Pages: 11-15
• [Presentation] 嗅覚障害の病態研究における分子イメージングの応用 (2012)
  • Author(s): 志賀英明
  • Organizer: 日本味と匂学会第46回大会研究奨励賞受賞講演
  • Place of Presentation: 大阪市
  • Year and Date: 20121003-1005
• [Presentation] Clinical diagnosis ofthe olfactory nerve transportfunction. (2012)
  • Author(s): Shiga, H.etal .
  • Organizer: The 15th International Symposium on Olfaction and Taste.
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20120623-0627
• [Presentation] 嗅覚障害と嗅神経輸送機能の臨床診断 (2012)
  • Author(s): 志賀英明
  • Organizer: 日本薬学会第132 年会シンポジウム
  • Place of Presentation: 札幌市
  • Year and Date: 20120328-0331
• [Presentation] Reduced olfactory nervetransport function in patients with olfactory disorders. (2011)
  • Author(s): 志賀英明、他.
  • Organizer: 日本味と匂学会第45回大会 シンポジウム
  • Place of Presentation: 金沢市
  • Year and Date: 20111005-1007
• [Presentation] 末梢嗅神経を介した脳内への微小粒子の輸送-嗅覚障害における課題- (2011)
  • Author(s): 志賀英明
  • Organizer: 第35回日本医用エアロゾル研究会シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 20110902-0903
• [Presentation] Olfactory bulbneurogenesis and olfactory nervetransport. Keystone symposia (2011)
  • Author(s): Shiga, H. et al.
  • Organizer: Adultneurogenesis.
  • Place of Presentation: Taos, USA
  • Year and Date: 20110109-0114
• [Presentation] Thalliumolfacto-scintigraphy visualizesnasal transport to the olfactory bulb. (2010)
  • Author(s): Shiga, H. et al.
  • Organizer: The 29thInternational Symposium onInfection and Allergy of the Nose.
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 20100620-0624
• [Presentation] Regeneration of olfactory nerve is accelerated by oral intake of TJ-137 (Chinesemedicine; Kamikihitou) in vivo. (2010)
  • Author(s): Shiga, H. et al.
  • Organizer: The 29 th International Symposium on Infection and Allergy of the Nose.
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 20100620-0624
• [Presentation] 嗅神経再生診断における分子イメージングの応用 (2009)
  • Author(s): 志賀英明、他
  • Organizer: 第48回日本鼻科学会 シンポジウム
  • Place of Presentation: 松江市
  • Year and Date: 20091009-1003
• [Presentation] Clinical imaging of thallium transport in the humanolfactory nerve. (2009)
  • Author(s): Shiga, H. e t a l .
  • Organizer: 2009 World molecularimaging congress.
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20090923-0926
• [Book] Innovative imagingof olfactory nerve connectivity "Thallium-201 olfacto-scintigraphy". Reimer, A. (eds); Horizons in World Physics (2011)
  • Author(s): Shiga, H. et al.
  • Total Pages: 223-231
  • Publisher: Nova Science Publishers, New York. 273
• [Remarks] 金沢医科大学 耳鼻咽喉科学 頭頸部外科学:研究
  • URL: http://www.kanazawa-med.ac.jp/ent/006kenkyu.html