2011 Fiscal Year Final Research Report
Olfactory regenerative medicine by granulocyte-colony stimulating factor
| Project/Area Number |
21592176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONODA Tomoo 岡山大学, 岡山大学病院, 助教 (20420482)
YOSHINOBU Junko 岡山大学, 医学部, 技術職員 (80448224)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 嗅細胞 / 再生 / 骨髄移植 / G-CSF / メチマゾール / 嗅組織幹細胞 |
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| Research Abstract |
A statistical analysis demonstrated significantly that the early administration of G-CSF(granulocyte-colony stimulating factor) was appropriate to increase the engraftment rate of bone marrow-derived cells into the olfactory epithelium. Moreover, cells with double-immunostaining for GFP(green fluorescence protein) and OMP(olfactory marker protein) and so on were found in the olfactory epithelium of recipient mice, which suggested that bone marrow-derived cells are engrafted as stem cells of the olfactory tissue. Thus, the early administration of G-CSF after insult to the olfactory tissue is suggested to be effective to olfactory regenerative medicine using bone marrow cells.
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[Journal Article]2009
Author(s)
Orita S, Yoshinobu J, Orita Y, Tsujigiwa H, Kakiuchi M, Nagatsuka H, Nomiya S, Nagai N, Nishizaki K
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Journal Title
Am J Rhinol Allergy
Volume: 23巻
Pages: 135-138
Peer Reviewed
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