The development of a new treatment for taste impairment using difructose as an enhancer of zinc absorption.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592194
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokushima
• Principal Investigator: TAKEDA Noriaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30206982)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Shigeru 十文字学園女子大学, 人間生活部, 教授 (70093896)
• Project Period (FY): 2009 – 2011
• Keywords: 味覚障害 / 亜鉛欠乏 / ACE活性比 / 亜鉛補充療法 / オリゴ糖

Research Abstract

We developed the ratio of apo/ holo activities of angiotensin coverting enzyme(ACR ratio) in the serum and examined patients with taste impairment and healthy subjects for their zinc nutrition using ACE ration as an index. In addition to a significant increase in ACE ratio in taste impairment patients with low concentrations of zinc in serum, ACE ratio was also significant elevated in taste impairment patients with normal value of zinc. These finding indicate that zinc deficiency is a predominant factor underlying taste impairment even when zinc concentrations are within normal ranges in serum. But, there were no differences in dietary zinc intake between patients and age-adjusted healthy subjects, suggesting that patients with taste impairment have malabsorption of dietary zinc in the gastrointestinal tract. We then examined the effects of zinc supplementation with difructose that enhances the absorption of zinc on taste impairment and showed its favorable efficacy. It is suggested that zinc supplementation with difructose will be a new treatment in patients woth refractory taste impairment.

Research Products

• [Journal Article] Effects of dietary zinc deprivation on zinc concentration and ratio of apo/ holo-activities of angiotensin converting enzyme in serum of mice (2011)
  • Author(s): N. Sarukura, S. Takai, S. Ikemoto, T. Korin, Y. Ueda, Y. Kitamura, B. Kalubi, S. Yamamoto and N. Takeda
  • Journal Title: Auris Nasus Larynx Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dietary intake and dietary effects on zinc nutrition in healthy Japanese living in the central area of Japan (2011)
  • Author(s): N. Sarukura, M. Kogirima, S. Takai, S. Ikemoto, T. Korin, Y. Ueda, Y. Kitamura, B. Kalubi, S. Yamamoto and N. Takeda
  • Journal Title: J. Med. Invest Volume: 58 Pages: 203-209
  • Peer Reviewed
• [Journal Article] Effects of zinc supplementation on serum zinc concentration and ratio of apo/ holo-activities of angiotensin converting enzyme in patients with taste impairment (2010)
  • Author(s): T. Takaoka, N. Sarukura, C. Ueda, Y. Kitamura, B. Kalubi, N. Toda, K. Abe, S. Yamamoto and N. Takeda
  • Journal Title: Auris Nasus Larynx Volume: 37 Pages: 190-194
  • DOI: DOI:10.1016/j.anl.2009.07.003
  • Peer Reviewed
• [Journal Article] A Zinc Containing Compound, Polaprezinc, is Effective for Patients with Taste Disorders : Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study (2009)
  • Author(s): M. Sakagami, M. Ikeda, H. Tomita, A. Ikui, T. Aiba, N. Takeda, A. Inokuchi, Y. Kurono, M. Nakashima, Y. Sibasaki and O. Yotsuya
  • Journal Title: Acta Otolaryngol Volume: 129 Pages: 1115-1120
  • DOI: DOI:10.1080/00016480802552550
  • Peer Reviewed
• [Presentation] 栄養素センサー研究の新展開:長寿健康社会のための栄養薬学:味覚受容と味覚障害 (2011)
  • Author(s): 武田憲昭
  • Organizer: 日本薬学会第131年会シンポジウム
  • Place of Presentation: ツインメッセ静岡(静岡)
  • Year and Date: 2011-03-29
• [Presentation] 亜鉛酵素・トランスポーター研究の最前線:亜鉛酵素「アンギオテンシン変換酵素」活性比と味覚障害患者の亜鉛栄養状態の評価 (2009)
  • Author(s): 武田憲昭
  • Organizer: 第20回日本微量元素学会シンポジウム
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2009-07-03