2011 Fiscal Year Final Research Report
Experimental study of vascularized flap preparation in a tissue engineering chamber
| Project/Area Number |
21592289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UENO Masaki 香川大学, 医学部, 準教授
HAMAMOTO Yhusuke 香川大学, 医学部, 助教
KOGURE Tetukuni 香川大学, 医学部, 助教
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| Project Period (FY) |
2009 – 2011
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| Keywords | 多血小板血漿 / FGF-2 / 細胞増殖因子 / 細胞外マトリックス / 再生組織 |
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| Research Abstract |
We evaluated a method to regenerate soft tissue flap in a tissue engineering chamber(TEC) as a site of regeneration by concomitantly using an AV bundle, artificial dermis, FGF-2, and platelet-rich plasma(PRP). The samples were divided into control, FGF-2, non-activated PRP, activated PRP, non-activated PRP+ FGF-2, and activated PRP+ FGF-2 groups, and the amount of regenerated tissue, degree of maturation of organization were evaluated. Results : Non-activated PRP induced more satisfactory regeneration of vascularized soft tissue than Activated PRP. Regenerated tissue with the highest degree of maturation was obtained in the non-activated PRP+ FGF-2group. The results indicate that the simultaneous use of non-activated PRP and FGF-2 is advantageous for the regeneration of vascularized soft tissue in a TEC.
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