2011 Fiscal Year Final Research Report
Role of matrix proteins on the differentiation and activity of hard tissue forming cells and calcification during tooth formation.
| Project/Area Number |
21592329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
UCHIDA Takashi 広島大学, 大学院・医歯薬学総合研究科, 教授 (50150305)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯の発生 / エナメル蛋白 / アメロブラスチン / 歯根形成 / 細胞増殖 / 細胞分化 |
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| Research Abstract |
This study clarified that ameloblastin, one of the enamel matrix protein, suppressed mitotic activity and raised expression of amelogenin and enamelin of the ameloblat-linage cell in vitro, and was essential for normal mitosis and differentiation of cells of Hertwig' s epithelial root sheath during root formation in vivo. Moreover, ameloblastin is supposed to be one of the candidate molecules of inducing differentiation of odontoblasts and cementocytes.
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