2011 Fiscal Year Final Research Report
Reguraltory mechanisms of neuronal activity in the superior salivatory nucleus by feeding-related peptides.
| Project/Area Number |
21592361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MITOH Yoshihiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20240872)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Ryuji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157268)
KOBASHI Motoi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80161967)
FUJITA Masako 岡山大学, 大学院・医歯薬学総合研究科, 助手 (40156881)
ICHIKAWA Hiroyuki 東北大学, 大学院・歯学研究科, 教授 (20193435)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔生理学 / 上唾液核ニューロン / 摂食関連ペプチド / ホールセルパッチクランプ法 / 免疫組織化学 / 視床下部 / 脳幹 |
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| Research Abstract |
The superior salivatory nucleus(SSN) neurons which is the primary parasympathetic center of the submandibular and sublingual salivary glands in rats were excited by orexins, one of feeding-related peptides, from lateral hypothalamic neurons(feeding center). The excitation in SSN neurons was completely inhibited by antagonists for OX1R and OX2R, orexins receptors subtypes. Additionally, SSN neurons showed immunoreactivities for OX1R and OX2R, suggesting that the excitation is mediated by OX1R and OX2R. Orexin-induced excitation in SSN neurons may be involved in abundant salivation in feeding.
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