2011 Fiscal Year Final Research Report
Immune regulation of oral disease by co-signal molecule B7-H3 and the novel receptor.
| Project/Area Number |
21592385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Dokkyo Medical University (2010-2011)
Tokyo Medical and Dental University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Miyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90255654)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫 / 感染 / 炎症 |
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| Research Abstract |
Co-signal molecules play important roles in positively or negatively regulate cell responses. We previously reported that new cosignal ligand murine B7-H3 and the receptor TLT-2 enhance T cell responses. Here we investigate the precise mechanisms and found, in human system, B7-H3 upregulate T cell responses through the ligation with TLT-2, too. We also clarified TLT-2 upregulates anti-tumor immunity through the enhancement of cytotoxicity by CD8^+T cells. These suggest that B7-H3.TLT-2 enhances anti-tumor immunity and imply that strong or continuous B7-H3.TLT-2 signaling lowers TLT-2.
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