2011 Fiscal Year Final Research Report
Health effects from radiation exposure of the fetus and children
| Project/Area Number |
21610029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
SHIMADA Yoshiya 独立行政法人放射線医学総合研究所, 放射線防護研究センター, プログラムリーダー (10201550)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Mayumi 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (70218204)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKINUMA Shizuko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (20392219)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 健康影響 / 胎児 / 放射線被ばく |
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| Research Abstract |
Assessing the impact of radiation exposure during fetal development and childhood, and identifying protective measures are matters of urgency. Using a mouse model, we analyzed the effect of the age-at-exposure on lifespan shortening, the accumulation of mutations in tissues, and the mutation frequency in induced cancers. The newborn period was found to be the most radiation-sensitive compared with fetal and adult stages, and the mutation frequency was altered in an age-dependent manner, providing an important oppotunity for further analysis.
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