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2011 Fiscal Year Final Research Report

Bioorganic Studies on the Key Natural Products Focused on Marine Symbiosis

Research Project

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Project/Area Number 21651091
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionUniversity of Tsukuba

Principal Investigator

KITA Masaki  筑波大学, 数理物質系, 准教授 (30335012)

Project Period (FY) 2009 – 2011
Keywords共生現象 / 天然物化学 / 単離と構造 / 生物活性
Research Abstract

We investigated the bioactive key natural products that serve the symbiotic relationship between host animals and symbionts or act as defense substances from predators in marine ecosystem. We determined the planar and partial relative structures of symbiodinolide, metabolite from a symbiotic dinoflagellate, by using unique degradation reactions.Wealso(a) established that this compound was a potent N-type Ca channel agonist. We discovered that the extract of an Alcyonarian coral shows potent inflammatory activity, and successfully isolated tryptamine and a water-soluble small molecule as active substances.

  • Research Products

    (16 results)

All 2012 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A. Angew2011

    • Author(s)
      M. Kita, Y. Hirayama, M. Sugiyama, and H. Kigoshi
    • Journal Title

      Chem. Int. Ed

      Volume: 50 Pages: 9871-9874

    • DOI

      DOI:10.1002/anie.201103802

    • Peer Reviewed
  • [Journal Article] Bioactive secondary metabolites from symbiotic marine dinoflagellates : symbiodinolide and durinskiols2010

    • Author(s)
      M. Kita, O. Ohno, C. Han, and D. Uemura
    • Journal Title

      Chem. Rec

      Volume: 10 Pages: 57-69

    • DOI

      DOI:10.1002/tcr.200900007

    • Peer Reviewed
  • [Journal Article] Marine huge molecules : the longest carbon chains in natural products2010

    • Author(s)
      M. Kita and D. Uemura
    • Journal Title

      Chem. Rec

      Volume: 10 Pages: 48-52

    • DOI

      DOI:10.1002/tcr.200900030

    • Peer Reviewed
  • [Journal Article] Recent aspects of chemical ecology.natural toxins, coral communities, and symbiotic relationships2009

    • Author(s)
      D. Uemura, M. Kita, H. Arimoto, and M. Kitamura
    • Journal Title

      Pure Appl. Chem

      Volume: 81 Pages: 1093-1111

    • DOI

      DOI:10.1351/PAC-CON-08-08-12

    • Peer Reviewed
  • [Journal Article] Duck-billed platypus venom peptides induce Ca^<2+> influx in neuroblastoma cells2009

    • Author(s)
      M. Kita, D. StC. Black, O. Ohno, K. Yamada, H. Kigoshi, and D. Uemura
    • Journal Title

      J. Am. Chem. Soc

      Volume: 131 Pages: 18038-18039

    • DOI

      DOI:10.1021/ja908148z

    • Peer Reviewed
  • [Journal Article] Determination of absolute configuration of C14.C23 fragment in symbiodinolide2009

    • Author(s)
      C. Han, Y. Yamano, M. Kita, H. Takamura, and D. Uemura
    • Journal Title

      Tetrahedron Lett

      Volume: 50 Pages: 8280-5282

    • DOI

      DOI:10.1016/j.tetlet.2009.07.014

    • Peer Reviewed
  • [Presentation] 有毒哺乳動物および海洋無脊椎動物由来の生物活性鍵物質に関する化学的研究2012

    • Author(s)
      北将樹
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス
    • Year and Date
      2012-03-28
  • [Presentation] 海洋生物由来の抗腫瘍性および抗炎症活性物質に関する研究2012

    • Author(s)
      河村篤, GISE, BARO, 北将樹, 木越英夫
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス
    • Year and Date
      2012-03-28
  • [Presentation] Bioorganic Studies on the Key Natural Products from Venomous Mammals and Marine Invertebrates2011

    • Author(s)
      M. Kita
    • Organizer
      1st Prof. G. W. K. Cavill Lecturship
    • Place of Presentation
      ニューサウスウェールズ大学(豪州シドニー)
    • Year and Date
      2011-11-01
  • [Presentation] ウミトサカ由来の炎症惹起物質2010

    • Author(s)
      冨田佳祐, 永野義仁, 北将樹, 木越英夫
    • Organizer
      日本化学会第4回関東支部大会
    • Place of Presentation
      筑波大学つくばキャンパス
    • Year and Date
      2010-08-30
  • [Presentation] 進化と共生に着目した生物現象鍵物質の化学的研究2010

    • Author(s)
      北将樹
    • Organizer
      筑波大学TIMS第12回機能性分子シンポジウム
    • Place of Presentation
      筑波大学つくばキャンパス
    • Year and Date
      2010-06-25
  • [Presentation] Bioactive Secondary Metabolites from Symbiotic Marine Dinoflagellates2010

    • Author(s)
      M. Kita
    • Organizer
      The Chemical Society of Japan (CSJ) Asian International Symposium
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2010-03-27
  • [Presentation] ウミトサカ由来の炎症惹起物質2010

    • Author(s)
      冨田佳祐, 永野義仁, 北将樹, 木越英夫
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2010-03-27
  • [Book] Marine Pharmacognosy : Trends and Applicatons2012

    • Author(s)
      M. Kita, T. Inuzuka, N. Maru, and and D. Uemura
    • Publisher
      CRC Press, Taylor Francis, New York(in press)
  • [Book] Comprehensive Natural Products Chemistry, 2nd edition2010

    • Author(s)
      M. Kita, M. Kitamura, and D. Uemura
    • Total Pages
      263-281
    • Publisher
      Elsevier, Amsterdam
  • [Remarks]

    • URL

      http://www.chem.tsukuba.ac.jp/kigoshi/j/top_j.html

URL: 

Published: 2013-07-31  

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