2011 Fiscal Year Final Research Report
Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target Proteins
| Project/Area Number |
21651092
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Minoru 東京大学, 分子細胞生物学研究所, 助教 (70526839)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生物活性分子の設計・合成 / タンパク質の自己分解 |
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| Research Abstract |
Protein knockdown can be achieved by the use of a small molecule that possesses affinity for both the target protein and ubiquitin ligase. As the ubiquitin ligase, we selected cIAP1 which specifically binds methylbestatin. Several hybrid molecules consisting of methylbestatin and a ligand for various proteins were designed and synthesized. These hybrid molecules induced selective decomposition of the target proteins.
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