Development of boronated peptide using anti-oxidative effect for neutron capture therapy

2011 Fiscal Year Final Research Report

• Project/Area Number: 21659337
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505) ; NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284) ; YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
• Project Period (FY): 2009 – 2011
• Keywords: 中性子捕捉療法

Research Abstract

We synthesize novel peptide which consist of boronated amino-acid. We succeed the synthesis pentamer and decamer of bolonophenylalanine by fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis. And we developed novel lipopeptide which containing boron, and liposome with it. We found the pre-treatment of glutathione modified the in vivo distribution of boron compounds.

Research Products

• [Journal Article] Matsumura A A clinicaltrial protocol for second linetreatment of malignant brain tumorswith BNCT at University of Tsukuba (2011)
  • Author(s): Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, Isobe T, Endo K, Takada T, YoshidaF, Shibata Y
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1819-1822
  • Peer Reviewed
• [Journal Article] Matsumura A Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma (2011)
  • Author(s): Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, MatsudaM, Tsurubuchi T, Shibata Y, TakanoS, Mizumoto M, Tsuboi K
  • Journal Title: arecursive partitioning analysis of BNCT patients Appl Radiat Isot Volume: 69 Pages: 1790-1792
  • Peer Reviewed
• [Journal Article] Matsumura A : Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT (2009)
  • Author(s): Shirakawa M, Yamamto T, Nakai K, Aburai K, Kawatobi S, Tsurubuchi T, Yamamoto Y, Yokoyama Y, Okuno H
  • Journal Title: Appl Radiat Isot Volume: 67 Pages: 84-7
  • DOI: DOI:10.1016/j.apradiso.2011.03.049
  • Peer Reviewed
• [Journal Article] Intracellular uptakeof a new boronated porphyrin EC032 (2009)
  • Author(s): Tsurubuchi T, Yamamoto T, Nakai K, Zaboronok A, Yoshida F, Miyakawa M, Shirakawa M, Yamamoto Y, Matsuda M, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 67 Pages: 94-6
  • Peer Reviewed
• [Presentation] MatsumuraA Evaluation of liposome modified to Boron-lipopeptide for BNCT (2012)
  • Author(s): Shirakawa M, Nakai K
  • Organizer: Workshop BNCT DAAD projectresearch and development in BNCT and charged particle therapy
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2012-03-02
• [Presentation] Clinical Trial of BNCT in University Tsukuba (2012)
  • Author(s): Shirakawa M, Nakai K, Matsumura A
  • Organizer: Workshop High LET particle therapyDAAD project research and development in BNCT and charged particle therapy
  • Place of Presentation: Marburg Germany
  • Year and Date: 2012-03-01
• [Presentation] Evaluation of liposome modifiedto Boron-lipopeptide for BNCT (2012)
  • Author(s): Shirakawa M, Nakai K, Matsumura A
  • Organizer: Clinical Trial of BNCT in University Tsukuba Workshop Modern particle Therapy DAAD project research and development in BNCT and charged particle therapy
  • Place of Presentation: Essen Germany
  • Year and Date: 2012-02-28
• [Presentation] Clinical Trial of BNCT in University (2012)
  • Author(s): Nakai K, Shirakawa M, Matsumura A
  • Organizer: Tsukuba Workshop Modern particleTherapy DAAD project researchand development in BNCT and chargedparticle therapy
  • Place of Presentation: EssenGermany
  • Year and Date: 2012-02-28
• [Presentation] Yoshida F (2011)
  • Author(s): Shirakawa M, Nakai K, Yamamoto T
  • Organizer: Matsumura A evaluation of liosome modified to Boron-lipopeptide for BNCT 6 thyoung researchers BNCT meeting
  • Place of Presentation: Taiwan
  • Year and Date: 2011-12-06
• [Presentation] Matsumura A et al (2010)
  • Author(s): Shirakawa M, Yamamoto T, Nakai K, Yoshida F
  • Organizer: Development of a fuctional liposome modified a novel lipid analog for BNCT. 14th International congresson neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-25
• [Presentation] et al Biodistributionof BSH-encapsulated boron liposomein mouse glioma (2010)
  • Author(s): Yoshida F, Nakai K, Yamamoto T, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-25
• [Presentation] ほか、脳腫瘍に対するBNCT:筑波大学臨床研究の現況 (2010)
  • Author(s): 中井啓, 山本哲哉, 松村明
  • Organizer: 第7回日本中性子捕捉療法学会学術集会
  • Year and Date: 2010-08-05
• [Presentation] et al clinicalresult and adjuvant therapy for glioblastoma with BNCT treatedpatients (2009)
  • Author(s): Nakai K, Matsumura A
  • Organizer: Young Researchers BNCTmeeting
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2009-09-29
• [Presentation] et al Evaluation of a novel liposome modified membrane permeability peptide for BNCT (2009)
  • Author(s): Shirakawa M, Matsumura A
  • Organizer: Young Researchers BNCT meeting
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2009-09-29