2011 Fiscal Year Final Research Report
Relationship between Biophysical Properties and Microstructure of Actin Stress Fibers
| Project/Area Number |
21680039
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
DEGUCHI Shinji 東北大学, 大学院・工学研究科, 准教授 (30379713)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ストレスファイバ / バイオメカニクス / メカノセンサー / メカノバイオロジー / 生物物理 / 細胞骨格 / 非筋アクトミオシン |
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| Research Abstract |
Stress fibers play a key role in regulation of cell homeostasis. Here we investigated their biophysical properties and microstructure. Particularly, we developed a method to isolate stress fibers that are intact with regard to structure (confirmed by western blotting and electron microscopy)and function(confirmed by a contractility assay). We then submitted a molecular mechanism that may underlie the cell shortening-induced disassembly of stress fibers.
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