2012 Fiscal Year Final Research Report
Structural and Functional Analysis of Paralytic Neurotoxins from Terrestrial Mammals
| Project/Area Number |
21681028
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KITA Masaki 筑波大学, 数理物質系, 准教授 (30335012)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 天然物化学 / 麻痺性神経毒 / 単離と構造 / 生物活性 / 哺乳動物 |
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| Research Abstract |
We investigated the structure and functions of paralytic neurotoxins from terrestrial venomous mammals. A neurotoxin (5 kDa) was almost purified from the salivary gland extracts of the short-tailed shrew Blarina brevicauda. From the venom fluidof the duck-bill platypus Ornithorhynchus anatinus, 11 unique neurotoxins, including a heptapeptide HDHPNPR, were identified and their biological activities have beencharacterized. We also established that platypus venom contains kallikrein-type protease(s), as with reptilian and shrew venom. The present findings may lead to the development of valuable pain-relief or vasoactive substances.
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[Journal Article] Fluorescent aplyronine A: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells.2012
Author(s)
M. Kita, K. Yoneda, Y. Hirayama, K. Yamagishi, Y. Saito, Y. Sugiyama, Y. Miwa, O. Ohno, M. Morita, K. Suenaga, and H. Kigoshi
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Journal Title
ChemBioChem
Volume: 13
Pages: 1754-1758
DOI
Peer Reviewed
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